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Riedel thyroiditis is a fibroinflammatory disorder of the thyroid gland, occurring more frequently in females, characterized a large, hard thyroid mass, and presenting with pressure symptoms (breathing difficulB,ties and dysphagia) or voice hoarseness and aphonia (impingement of recurrent laryngeal nerve). It can often be associated with extracervical fibroinflammatory disorders such as retroperitoneal fibrosis, primary scleroisng cholangitis and autoimmune diseases such as Hashimoto struma, Addison disease, and Biermer disease.
Biomarker and diagnostic research for IgG4-related thyroid disease has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for IgG4-related thyroid disease.
135 publications have been identified in PubMed for IgG4-related thyroid disease. Research spans Basic Science / Preclinical (42%), Epidemiology / Natural History (16%), and Review / Meta-Analysis (13%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 57 | 42% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 11:12 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about IgG4-related thyroid disease
Disease patterns and progression
21 |
16% |
Research summaries | 17 | 13% |
Clinical study results | 15 | 11% |
Patient case studies | 13 | 10% |
Testing and diagnosis research | 11 | 8% |
Other research | 1 | 1% |
Zimmermann J (2026). [PMID: 41807831](https://pubmed.ncbi.nlm.nih.gov/41807831/). *Nat Chem Biol*. [Basic Science / Preclinical]
Meelker González R (2026). [PMID: 41723106](https://pubmed.ncbi.nlm.nih.gov/41723106/). *Nat Commun*. [Basic Science / Preclinical]
John F (2026). [PMID: 41417462](https://pubmed.ncbi.nlm.nih.gov/41417462/). *Clin Cancer Res*. [Basic Science / Preclinical]
Sheth SS (2026). [PMID: 41863031](https://pubmed.ncbi.nlm.nih.gov/41863031/). *Ann Otol Rhinol Laryngol*. [Case Report / Case Series]
Streinu DR (2026). [PMID: 41976829](https://pubmed.ncbi.nlm.nih.gov/41976829/). *J Clin Med*. [Case Report / Case Series]
Gosi SKY (2026). [PMID: 30725988](https://pubmed.ncbi.nlm.nih.gov/30725988/). *Unknown Journal*. [Epidemiology / Natural History]
Buchberger A (2026). [PMID: 41030128](https://pubmed.ncbi.nlm.nih.gov/41030128/). *Ann Clin Transl Neurol*. [Case Report / Case Series]
Zhao T (2026). [PMID: 41686604](https://pubmed.ncbi.nlm.nih.gov/41686604/). *Medicine (Baltimore)*. [Case Report / Case Series]
Mueller S (2026). [PMID: 41741657](https://pubmed.ncbi.nlm.nih.gov/41741657/). *Nature*. [Epidemiology / Natural History]
Yanai AI (2026). [PMID: 42259572](https://pubmed.ncbi.nlm.nih.gov/42259572/). *BMJ Case Rep*. [Case Report / Case Series]
AI-curated news mentioning IgG4-related thyroid disease
Updated Sep 8, 2026
A forensic autopsy case report highlights a sudden cardiac death linked to extensive cardiovascular IgG4-related disease. This study contributes to the understanding of the disease's impact on cardiovascular health.
A recent case-based review explores the complexities of diagnosing eosinophilic pancreatitis versus IgG4-related diseases. This atypical case highlights the challenges in distinguishing between these conditions, which may have overlapping features.
A recent case study highlights multinervous cranial involvement in an adult patient with IgG4-related disease, affecting facial, infraorbital, auriculotemporal, and optic nerves. This research adds to the understanding of the disease's neurological manifestations.