TYK2 function has not been fully characterized.

Immunodeficiency 35 is associated with mutations in the TYK2 gene on chromosome 19.

Genetic testing for TYK2 is available. Testing is considered confirmatory for diagnosis.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

No clinical trials have been registered for immunodeficiency 35.

12 publications have been identified in PubMed for immunodeficiency 35. Research spans Basic Science / Preclinical (42%), Case Report / Case Series (33%), and Other (8%).

Recent Publications

• Hafsi W (2026). [PMID: 30247822](https://pubmed.ncbi.nlm.nih.gov/30247822/). *Unknown Journal*. [Case Report / Case Series]

• Hennighausen L (2025). [PMID: 41327031](https://pubmed.ncbi.nlm.nih.gov/41327031/). *BMC Genomics*. [Basic Science / Preclinical]

• Gastaldi T (2025). [PMID: 40530418](https://pubmed.ncbi.nlm.nih.gov/40530418/). *iScience*. [Basic Science / Preclinical]

• Xie L (2025). [PMID: 40586332](https://pubmed.ncbi.nlm.nih.gov/40586332/). *Int J Immunopathol Pharmacol*. [Review / Meta-Analysis]

• Karjalainen A (2025). [PMID: 40025196](https://pubmed.ncbi.nlm.nih.gov/40025196/). *Cell Mol Life Sci*. [Basic Science / Preclinical]

• Sikhayeva N (2025). [PMID: 41465118](https://pubmed.ncbi.nlm.nih.gov/41465118/). *Genes (Basel)*. [Case Report / Case Series]

• Alimi A (2025). [PMID: 40949057](https://pubmed.ncbi.nlm.nih.gov/40949057/). *J Hum Immun*. [Case Report / Case Series]

• Johnson B (2024). [PMID: 39403378](https://pubmed.ncbi.nlm.nih.gov/39403378/). *Front Immunol*. [Basic Science / Preclinical]

• Gao Y (2024). [PMID: 38896258](https://pubmed.ncbi.nlm.nih.gov/38896258/). *J Clin Immunol*. [Case Report / Case Series]

• Obeidat L (2024). [PMID: 39268404](https://pubmed.ncbi.nlm.nih.gov/39268404/). *Biomed Rep*. [Epidemiology / Natural History]