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insulin autoimmune syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

insulin autoimmune syndrome

MONDO:0018465

Also known as:Hirata diseaseinsulin autoimmune hypoglycemia

Overview

Insulin autoimmune syndrome is a rare condition that causes low blood sugar (hypoglycemia). This occurs because the body begins to make a specific kind of protein called antibodies to attack insulin. Insulin is a naturally occurring hormone that is responsible for keeping blood sugar at a normal level. When blood sugar levels get too high, insulin helps to store the sugar for future use. People affected by insulin autoimmune syndrome have antibodies that attack insulin, causing it to work too hard and the level of blood sugar to become too low. Insulin autoimmune syndrome most often begins during adulthood.

Diagnosis

Biomarker and diagnostic research for insulin autoimmune syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for insulin autoimmune syndrome.

52 publications have been identified in PubMed for insulin autoimmune syndrome. Research spans Case Report / Case Series (75%), Diagnostic / Biomarker (8%), and Review / Meta-Analysis (8%).

Research Type	Count	% of Total
Patient case studies	39	75%

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 2:53 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:411593

GARD

Genetic and Rare Diseases Info Center

GARD:10808

Questions for Your Care Team

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Kisho

insulin autoimmune syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Dual Thiol Drug-Induced Insulin Autoimmune Syndrome in a Non-Asian Patient Carrying HLA-DRB1*04:06: A Case Report and Literature Review.

Diagnostic pitfalls in endogenous hyperinsulinaemic hypoglycaemia due to insulin autoimmune syndrome.

Alpha-lipoic acid as a trigger of insulin autoimmune syndrome: Current evidence, a case-based approach, diagnostic pitfalls, and practical management.

insulin autoimmune syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Dual Thiol Drug-Induced Insulin Autoimmune Syndrome in a Non-Asian Patient Carrying HLA-DRB1*04:06: A Case Report and Literature Review.

Diagnostic pitfalls in endogenous hyperinsulinaemic hypoglycaemia due to insulin autoimmune syndrome.

Alpha-lipoic acid as a trigger of insulin autoimmune syndrome: Current evidence, a case-based approach, diagnostic pitfalls, and practical management.