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intellectual disability, X-linked 23 (MRX23) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

intellectual disability, X-linked 23

MONDO:0010230

Also known as:MRX23mental retardation, X-linked 23

Overview

GeneticsX-linked

Clinical Presentation

Features include: Intellectual disability.

Organ System	Phenotype Count	Example Features
Brain and nerves	1	Intellectual disability

Explore clinical features

Diagnosis

Biomarker and diagnostic research for intellectual disability, X-linked 23 has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for intellectual disability, X-linked 23.

82 publications have been identified in PubMed for intellectual disability, X-linked 23. Research spans Basic Science / Preclinical (27%), Epidemiology / Natural History (21%), and Clinical Trial Publication (17%).

Research Type	Count	% of Total
Laboratory research	22	27%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:55 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:300046

GARD

Genetic and Rare Diseases Info Center

GARD:22666

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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Kisho

intellectual disability, X-linked 23

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Heterozygous loss-of-function variant in METTL5 is associated with intellectual disability.

Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization.

Bi-allelic GSPT1 variants are associated with a syndromic neurodevelopmental disorder characterized by intellectual disability and microcephaly.

Use of paracetamol during pregnancy unchanged in the EU

intellectual disability, X-linked 23

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Heterozygous loss-of-function variant in METTL5 is associated with intellectual disability.

Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization.

Bi-allelic GSPT1 variants are associated with a syndromic neurodevelopmental disorder characterized by intellectual disability and microcephaly.

Use of paracetamol during pregnancy unchanged in the EU