BRWD3 encodes bromodomain and WD repeat domain containing 3 (1,802 aa). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape Highest expression in Cells EBV-transformed lymphocytes (11.9 TPM) and Ovary (10.1 TPM).

Intellectual disability, X-linked 93 is associated with mutations in the BRWD3 gene on chromosome X.

BRWD3 is classified as a druggable target with score 0.0.

Genetic testing for BRWD3 is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for intellectual disability, X-linked 93 has been reported in the published literature.

Phenotype severity distribution: 2 always present features, 1 very common feature, 2 common features.

No clinical trials have been registered for intellectual disability, X-linked 93.

10 publications have been identified in PubMed for intellectual disability, X-linked 93. Research spans Diagnostic / Biomarker (30%), Epidemiology / Natural History (30%), and Basic Science / Preclinical (20%).

Recent Publications

• Kayhan G (2026). [PMID: 41751633](https://pubmed.ncbi.nlm.nih.gov/41751633/). *Genes (Basel)*. [Epidemiology / Natural History]

• Lubbers K (2026). [PMID: 39395123](https://pubmed.ncbi.nlm.nih.gov/39395123/). *J Autism Dev Disord*. [Epidemiology / Natural History]

• Lee B (2025). [PMID: 40782865](https://pubmed.ncbi.nlm.nih.gov/40782865/). *Int J Biol Macromol*. [Basic Science / Preclinical]

• Yska HAF (2025). [PMID: 39777696](https://pubmed.ncbi.nlm.nih.gov/39777696/). *J Inherit Metab Dis*. [Epidemiology / Natural History]

• Likhitweerawong N (2025). [PMID: 41298566](https://pubmed.ncbi.nlm.nih.gov/41298566/). *Sci Rep*. [Diagnostic / Biomarker]

• Yıldız N (2024). [PMID: 39003968](https://pubmed.ncbi.nlm.nih.gov/39003968/). *Epilepsy Res*. [Diagnostic / Biomarker]

• Trajkova S (2024). [PMID: 38751117](https://pubmed.ncbi.nlm.nih.gov/38751117/). *HGG Adv*. [Diagnostic / Biomarker]

• Peri F (2024). [PMID: 39002354](https://pubmed.ncbi.nlm.nih.gov/39002354/). *Pediatr Neurol*. [Clinical Trial Publication]

• Vega-Hanna L (2024). [PMID: 39795538](https://pubmed.ncbi.nlm.nih.gov/39795538/). *Diagnostics (Basel)*. [Basic Science / Preclinical]

• Spreghini MR (2024). [PMID: 39408308](https://pubmed.ncbi.nlm.nih.gov/39408308/). *Nutrients*. [Case Report / Case Series]