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A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.
Biomarker and diagnostic research for intrahepatic cholangiocarcinoma has been reported in the published literature.
109 clinical trials registered, 57 recruiting. Interventions under study include drug therapy, procedural interventions, other interventions, and biologic therapy. Pipeline includes 2 PHASE4, 2 PHASE3, 62 PHASE2. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06860477](https://clinicaltrials.gov/study/NCT06860477) |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 9:53 AM UTC
Genetic and Rare Diseases Info Center
Cryoablation Combined With Lenvatinib Plus Tislelizumab Compared With FOLFOX in Patients With Advanced Intrahepatic Cholangiocarcinoma (CASTLE-ZS-01) |
PHASE2 |
Fudan University |
RECRUITING |
[NCT07101237](https://clinicaltrials.gov/study/NCT07101237) | An Exploratory Study on Developing an Integrated Approach Combining Multimodal Imaging and Multi-omics Characterization of Tumor Heterogeneity for Precision Diagnosis and Treatment Optimization in Liver Cancer. | — | Peking Union Medical College Hospital | RECRUITING |
[NCT06298968](https://clinicaltrials.gov/study/NCT06298968) | Combined Therapy Using Gemcitabine and Cisplatin Chemotherapy, Lenvatinib and Adebrelimab for Patients With Advanced and Unresectable Intrahepatic Cholangiocarcinoma | PHASE2 | Nanfang Hospital, Southern Medical University | RECRUITING |
[NCT06375915](https://clinicaltrials.gov/study/NCT06375915) | Precision Medicine in Patients With Unresectable CholAngiocarcinoma: RadioEmbolization and Combined Biological Therapy | PHASE2 | Francesco De Cobelli | RECRUITING |
[NCT06718257](https://clinicaltrials.gov/study/NCT06718257) | Chemotherapy Combined with Immunotherapy and Targeted Therapy in Cholangiocarcinoma | — | Second Affiliated Hospital, Zhejiang University, School of Medicine | RECRUITING |
344 publications have been identified in PubMed for intrahepatic cholangiocarcinoma. Research spans Basic Science / Preclinical (30%), Review / Meta-Analysis (25%), and Diagnostic / Biomarker (15%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 104 | 30% |
Research summaries | 87 | 25% |
Testing and diagnosis research | 51 | 15% |
Disease patterns and progression | 23 | 7% |
Patient case studies | 22 | 6% |
Other research | 20 | 6% |
Clinical study results | 19 | 6% |
New treatment approaches | 18 | 5% |
Beaufrère A (2026). [PMID: 41541502](https://pubmed.ncbi.nlm.nih.gov/41541502/). *JHEP Rep*. [Diagnostic / Biomarker]
Ma Y (2026). [PMID: 41519216](https://pubmed.ncbi.nlm.nih.gov/41519216/). *Cell Signal*. [Gene Therapy / Novel Therapeutics]
Yang X (2026). [PMID: 42169873](https://pubmed.ncbi.nlm.nih.gov/42169873/). *J Gastrointest Oncol*. [Epidemiology / Natural History]
Machado MA (2026). [PMID: 41530598](https://pubmed.ncbi.nlm.nih.gov/41530598/). *Ann Surg Oncol*. [Case Report / Case Series]
Georgiades C (2026). [PMID: 41528229](https://pubmed.ncbi.nlm.nih.gov/41528229/). *Radiology*. [Other]
Vanterpool G Jr (2026). [PMID: 42186986](https://pubmed.ncbi.nlm.nih.gov/42186986/). *Am Surg*. [Clinical Trial Publication]
He X (2026). [PMID: 40603768](https://pubmed.ncbi.nlm.nih.gov/40603768/). *Eur Radiol*. [Epidemiology / Natural History]
Zhou X (2026). [PMID: 41628547](https://pubmed.ncbi.nlm.nih.gov/41628547/). *Eur J Surg Oncol*. [Diagnostic / Biomarker]
Arya S (2026). [PMID: 42243894](https://pubmed.ncbi.nlm.nih.gov/42243894/). *J Exp Clin Cancer Res*. [Gene Therapy / Novel Therapeutics]
Oyenuga M (2026). [PMID: 42169949](https://pubmed.ncbi.nlm.nih.gov/42169949/). *J Gastrointest Oncol*. [Other]
AI-curated news mentioning intrahepatic cholangiocarcinoma
Updated Aug 28, 2026
A case study highlights the cholangioblastic variant of intrahepatic cholangiocarcinoma in a young adult with situs inversus totalis. This discovery adds to the understanding of rare cancer presentations and their potential associations.
A recent study investigates whether the surgical approach impacts benchmark attainment in intrahepatic cholangiocarcinoma. Findings suggest that surgical techniques may play a significant role in patient outcomes.
A recent study highlights the incidental detection of intrahepatic cholangiocarcinoma in patients who underwent living-donor liver transplantation for polycystic liver disease. This finding underscores the need for careful post-transplant monitoring in this patient population.