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isolated ankyloblepharon filiforme adnatum - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

isolated ankyloblepharon filiforme adnatum

MONDO:0019626

Overview

Isolated ankyloblepharon filiforme adnatum (AFA) is characterized by the presence of single or multiple thin bands of connective tissue between the upper and lower eyelids, preventing full opening of the eye. Several cases have been reported. It can occur sporadically or following an autosomal dominant transmission pattern. In some cases, AFA can be associated with other disorders, such as trisomy 18. The bands should be removed to avoid amblyopia and this can easily be performed in the neonatal period by cutting with tissue scissors.

ResearchLimited published research (2 articles)

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for isolated ankyloblepharon filiforme adnatum.

2 publications have been identified in PubMed for isolated ankyloblepharon filiforme adnatum. Research spans Case Report / Case Series (100%).

Recent Publications

Nakamura C (2026). [PMID: 41798564](https://pubmed.ncbi.nlm.nih.gov/41798564/). *Cureus*. [Case Report / Case Series]
Al Khathami A (2025). [PMID: 41070209](https://pubmed.ncbi.nlm.nih.gov/41070209/). *J Surg Case Rep*. [Case Report / Case Series]

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 1:03 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:91397

GARD

Genetic and Rare Diseases Info Center

GARD:19168

Questions for Your Care Team

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isolated ankyloblepharon filiforme adnatum

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team