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isolated cleft palate - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

isolated cleft palate

MONDO:0007336

Also known as:nonsyndromic cleft palateCPIcleft palate

Find Clinical TrialsTrials

Overview

A cleft palate that is not part of a larger syndrome.

GeneticsAutosomal dominant

Clinical Trials30 registered · 14 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include: Cleft palate, Increased overbite, Seizure, and Profound intellectual disability and 3 more.

Organ System	Phenotype Count	Example Features
Brain and nerves	2	Seizure, Profound intellectual disability
Head and neck

Diagnosis

Biomarker and diagnostic research for isolated cleft palate has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

30 clinical trials registered, 14 recruiting. Interventions under study include other interventions, procedural interventions, medical devices, and drug therapy. Pipeline includes 2 PHASE4, 2 PHASE3, 1 PHASE1. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT01601171](https://clinicaltrials.gov/study/NCT01601171)

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 1:53 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:119540

GARD

Genetic and Rare Diseases Info Center

GARD:1896

Questions for Your Care Team

→Are any of the 30 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Laboratory research	59	24%
Research summaries	57	24%
Clinical study results	45	19%
Disease patterns and progression	44	18%
Patient case studies	18	7%
Other research	7	3%
Testing and diagnosis research	6	2%
New treatment approaches	6	2%

Kisho

isolated cleft palate

Overview

Clinical Presentation

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Questions for Your Care Team

Questions for Your Care Team

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isolated cleft palate

Overview

Clinical Presentation

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

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Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications