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kuru - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

kuru

MONDO:0006825

Also known as:kuru encephalopathy

Overview

A prion disease found exclusively among the Fore linguistic group natives of the highlands of new guinea. The illness is primarily restricted to adult females and children of both sexes. It is marked by the subacute onset of tremor and ataxia followed by motor weakness and incontinence. Death occurs within 3-6 months of disease onset. The condition is associated with ritual cannibalism, and has become rare since this practice has been discontinued. Pathologic features include a noninflammatory loss of neurons that is most prominent in the cerebellum, glial proliferation, and amyloid plaques. (From Adams et al., Principles of Neurology, 6th ed, p773)

Diagnosis

Biomarker and diagnostic research for kuru has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for kuru.

165 publications have been identified in PubMed for kuru. Kisho has analyzed 80 by research type. Research spans Basic Science / Preclinical (29%), Clinical Trial Publication (26%), and Review / Meta-Analysis (14%).

Research Type	Count	% of Total
Laboratory research	23	29%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 8:40 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:454745

GARD

Genetic and Rare Diseases Info Center

GARD:7617

Questions for Your Care Team

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kuru

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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