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A rare form of epileptic encephalopathy with spike-wave activation in sleep (EE-SWAS) characterized by various combinations of acquired cognitive, language, behavioral, and motor deficits associated with marked spike- and- wave activation in sleep. In Landau-Kleffner syndrome, receptive language is mainly affected, with an acquired auditory verbal agnosia.
Biomarker and diagnostic research for Landau-Kleffner syndrome has been reported in the published literature.
No clinical trials have been registered for Landau-Kleffner syndrome.
27 publications have been identified in PubMed for Landau-Kleffner syndrome. Research spans Review / Meta-Analysis (28%), Case Report / Case Series (28%), and Basic Science / Preclinical (24%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 7 | 28% |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:46 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Landau-Kleffner syndrome
7 |
28% |
Laboratory research | 6 | 24% |
Clinical study results | 2 | 8% |
Disease patterns and progression | 2 | 8% |
Testing and diagnosis research | 1 | 4% |
Al-Beltagi M (2026). [PMID: 42220948](https://pubmed.ncbi.nlm.nih.gov/42220948/). *World J Clin Pediatr*. [Review / Meta-Analysis]
Soto-Insuga V (2026). [PMID: 42044942](https://pubmed.ncbi.nlm.nih.gov/42044942/). *Neurologia (Engl Ed)*. [Clinical Trial Publication]
Lamônica D (2026). [PMID: 41526063](https://pubmed.ncbi.nlm.nih.gov/41526063/). *BMJ case reports*. [Diagnostic / Biomarker]
Sivaji AR (2026). [PMID: 41773574](https://pubmed.ncbi.nlm.nih.gov/41773574/). *Journal of child neurology*. [Basic Science / Preclinical]
İriş M (2026). [PMID: 41570778](https://pubmed.ncbi.nlm.nih.gov/41570778/). *Seizure*. [Epidemiology / Natural History]
Hsu CY (2026). [PMID: 42033809](https://pubmed.ncbi.nlm.nih.gov/42033809/). *Acta Neurol Taiwan*. [Case Report / Case Series]
Méndez-Álvarez AD (2025). [PMID: 40464423](https://pubmed.ncbi.nlm.nih.gov/40464423/). *Revista de neurologia*. [Review / Meta-Analysis]
Van Bogaert P (2025). [PMID: 39363819](https://pubmed.ncbi.nlm.nih.gov/39363819/). *Developmental medicine and child neurology*. [Case Report / Case Series]
Chen R (2025). [PMID: 41051942](https://pubmed.ncbi.nlm.nih.gov/41051942/). *Epilepsia open*. [Basic Science / Preclinical]
Andreoli L (2025). [PMID: 41161200](https://pubmed.ncbi.nlm.nih.gov/41161200/). *Epilepsy & behavior : E&B*. [Basic Science / Preclinical]