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A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.
Biomarker and diagnostic research for large cell neuroendocrine carcinoma has been reported in the published literature.
19 clinical trials registered, 6 recruiting. Interventions under study include drug therapy, biologic therapy, other interventions, and procedural interventions. Pipeline includes 10 PHASE2, 8 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06814496](https://clinicaltrials.gov/study/NCT06814496) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 12:51 AM UTC
Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors |
PHASE1 |
University of Arizona |
RECRUITING |
[NCT06176989](https://clinicaltrials.gov/study/NCT06176989) | Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors | PHASE2 | National Cancer Institute (NCI) | RECRUITING |
[NCT07080242](https://clinicaltrials.gov/study/NCT07080242) | Evaluating BL-M14D1 in Subjects With Locally Advanced or Metastatic Small Cell Lung Cancer and Neuroendocrine Tumors | PHASE1 | SystImmune Inc. | RECRUITING |
[NCT07278479](https://clinicaltrials.gov/study/NCT07278479) | Study of [212Pb]Pb-DOTAM-MAM279 ([212Pb]Pb-MP0712) in Patients With Small Cell Lung Cancer and Other DLL3 Expressing Solid Tumors | PHASE1 | Molecular Partners AG | RECRUITING |
[NCT07006727](https://clinicaltrials.gov/study/NCT07006727) | Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors | PHASE1 | Novartis Pharmaceuticals | RECRUITING |
210 publications have been identified in PubMed for large cell neuroendocrine carcinoma. Research spans Case Report / Case Series (38%), Review / Meta-Analysis (22%), and Basic Science / Preclinical (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 64 | 38% |
Research summaries | 37 | 22% |
Laboratory research | 22 | 13% |
Testing and diagnosis research | 17 | 10% |
Disease patterns and progression | 14 | 8% |
Clinical study results | 9 | 5% |
Other research | 5 | 3% |
Davis AJ (2026). [PMID: 42264414](https://pubmed.ncbi.nlm.nih.gov/42264414/). *Semin Ultrasound CT MR*. [Review / Meta-Analysis]
Yi X (2026). [PMID: 42222383](https://pubmed.ncbi.nlm.nih.gov/42222383/). *Front Oncol*. [Case Report / Case Series]
Put A (2026). [PMID: 41854102](https://pubmed.ncbi.nlm.nih.gov/41854102/). *Cancer Rep (Hoboken)*. [Basic Science / Preclinical]
Xu P (2026). [PMID: 41768248](https://pubmed.ncbi.nlm.nih.gov/41768248/). *Front Oncol*. [Case Report / Case Series]
Matsuoka R (2026). [PMID: 41581412](https://pubmed.ncbi.nlm.nih.gov/41581412/). *Cancer Treat Res Commun*. [Basic Science / Preclinical]
von Amsberg G (2026). [PMID: 41571001](https://pubmed.ncbi.nlm.nih.gov/41571001/). *Aktuelle Urol*. [Review / Meta-Analysis]
Tsukada A (2026). [PMID: 42208366](https://pubmed.ncbi.nlm.nih.gov/42208366/). *Lung Cancer*. [Review / Meta-Analysis]
Kong YH (2026). [PMID: 42236456](https://pubmed.ncbi.nlm.nih.gov/42236456/). *Zhonghua Jie He He Hu Xi Za Zhi*. [Review / Meta-Analysis]
Pei Y (2026). [PMID: 41674993](https://pubmed.ncbi.nlm.nih.gov/41674993/). *Transl Cancer Res*. [Diagnostic / Biomarker]
Kemik F (2026). [PMID: 40626442](https://pubmed.ncbi.nlm.nih.gov/40626442/). *Anticancer Drugs*. [Review / Meta-Analysis]
AI-curated news mentioning large cell neuroendocrine carcinoma
Updated Jul 28, 2026
Recent research highlights metastatic large cell neuroendocrine carcinoma as a rare cause of hypopituitarism. This discovery may influence future diagnostic and treatment approaches for patients presenting with pituitary dysfunction.
A case report and literature review on primary large cell neuroendocrine carcinoma of the pulmonary artery has been published, contributing to the understanding of this rare cancer type. The findings may inform future research and clinical approaches.
A recent publication discusses mixed large cell neuroendocrine carcinoma and adenocarcinoma of the cervix, highlighting its rarity and clinical significance. This research contributes to the understanding of this uncommon cancer type.