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late-onset familial hypoaldosteronism - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

late-onset familial hypoaldosteronism

MONDO:0035321

Also known as:Late-onset familial hyperreninemic hypoaldosteronismMild aldosterone synthase deficiency

Overview

A rare form of familial hypoaldosteronism characterized by adult onset of subnormal plasma aldosterone with elevated plasma renin activity, hyperkalemia, metabolic acidosis, and hypotension. Signs and symptoms are typically mild, and affected individuals may be clinically asymptomatic and diagnosed only after biochemical screening.

ResearchLimited published research (2 articles)

Diagnosis

Biomarker and diagnostic research for late-onset familial hypoaldosteronism has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for late-onset familial hypoaldosteronism.

2 publications have been identified in PubMed for late-onset familial hypoaldosteronism. Research spans Diagnostic / Biomarker (50%) and Epidemiology / Natural History (50%).

Recent Publications

Pande M (2025). [PMID: 40192663](https://pubmed.ncbi.nlm.nih.gov/40192663/). *Endocrinol Diabetes Metab Case Rep*. [Diagnostic / Biomarker]
Liu X (2024). [PMID: 38903768](https://pubmed.ncbi.nlm.nih.gov/38903768/). *Front Pediatr*. [Epidemiology / Natural History]

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:50 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:556037

GARD

Genetic and Rare Diseases Info Center

GARD:22244

Questions for Your Care Team

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late-onset familial hypoaldosteronism

Overview

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team