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late-onset focal dermal elastosis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

late-onset focal dermal elastosis

MONDO:0016437

Also known as:PXE-like late-onset focal dermal elastosispseudoxanthoma-like late-onset focal dermal elastosis

Overview

Late-onset focal dermal elastosis is a rare, acquired, dermis elastic tissue disorder characterized by a pseudoxanthoma elasticum-like papular eruption consisting of multiple, slowly progressive, asymptomatic, 2-5 mm, white to yellowish, non-follicular papules (that tend to form cobblestone plaques) predominantly distributed over the neck, axillae and flexural areas, with no systemic involvement. Skin biopsy reveals a focal increase of normal-appearing elastic tissue in the reticular dermis with no calcium deposits.

ResearchLimited published research (5 articles)

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for late-onset focal dermal elastosis.

5 publications have been identified in PubMed for late-onset focal dermal elastosis. Research spans Review / Meta-Analysis (60%) and Case Report / Case Series (40%).

Recent Publications

Aung T (2025). [PMID: 40859862](https://pubmed.ncbi.nlm.nih.gov/40859862/). *Australas J Dermatol*. [Review / Meta-Analysis]
Alrefaie SI (2025). [PMID: 40171012](https://pubmed.ncbi.nlm.nih.gov/40171012/). *Clin Case Rep*. [Case Report / Case Series]
El Jalkh J (2025). [PMID: 40407483](https://pubmed.ncbi.nlm.nih.gov/40407483/). *Dermatopathology (Basel)*. [Case Report / Case Series]
Alabdulaaly L (2025). [PMID: 39983090](https://pubmed.ncbi.nlm.nih.gov/39983090/). *Am J Dermatopathol*. [Review / Meta-Analysis]
Kossard S (2024). [PMID: 39412342](https://pubmed.ncbi.nlm.nih.gov/39412342/). *Am J Dermatopathol*. [Review / Meta-Analysis]

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 8:40 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:228227

GARD

Genetic and Rare Diseases Info Center

GARD:20578

Questions for Your Care Team

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late-onset focal dermal elastosis

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team