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Any left ventricular noncompaction in which the cause of the disease is a mutation in the MIB1 gene.
Features include: Left ventricular noncompaction and Left ventricular noncompaction cardiomyopathy.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Heart and blood vessels | 2 | Left ventricular noncompaction, Left ventricular noncompaction cardiomyopathy |
MIB1 encodes MIB E3 ubiquitin protein ligase 1 (1,006 aa). E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Highest expression in Artery Tibial (26.5 TPM) and Cervix Ectocervix (26.4 TPM).
Left ventricular noncompaction 7 is associated with mutations in the MIB1 gene on chromosome 18.
The MIB1 protein participates in Activated NOTCH1 Transmits Signal to the Nucleus pathway.
MIB1 is classified as a druggable target (Clinically Actionable, Enzyme, and Kinase categories) with score 0.0.
Genetic testing for MIB1 is available. Testing is considered confirmatory for diagnosis.
Biomarker and diagnostic research for left ventricular noncompaction 7 has been reported in the published literature.
No clinical trials have been registered for left ventricular noncompaction 7.
42 publications have been identified in PubMed for left ventricular noncompaction 7. Research spans Case Report / Case Series (29%), Basic Science / Preclinical (19%), and Epidemiology / Natural History (19%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 12 | 29% |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 8:11 PM UTC
Online Mendelian Inheritance in Man
Genetic and Rare Diseases Info Center
Laboratory research
8 |
19% |
Disease patterns and progression | 8 | 19% |
Testing and diagnosis research | 6 | 14% |
Research summaries | 5 | 12% |
Clinical study results | 2 | 5% |
Other research | 1 | 2% |
Aranzazu-Ceballos AD (2026). [PMID: 41766641](https://pubmed.ncbi.nlm.nih.gov/41766641/). *Cardiol Young*. [Case Report / Case Series]
Haque M (2026). [PMID: 41879597](https://pubmed.ncbi.nlm.nih.gov/41879597/). *JACC Case Rep*. [Case Report / Case Series]
Zhao Y (2026). [PMID: 41705901](https://pubmed.ncbi.nlm.nih.gov/41705901/). *Prenat Diagn*. [Basic Science / Preclinical]
Kurt H (2026). [PMID: 41728227](https://pubmed.ncbi.nlm.nih.gov/41728227/). *Eur Heart J Case Rep*. [Case Report / Case Series]
Huang W (2026). [PMID: 41998457](https://pubmed.ncbi.nlm.nih.gov/41998457/). *J Imaging Inform Med*. [Clinical Trial Publication]
Arslan A (2026). [PMID: 42165793](https://pubmed.ncbi.nlm.nih.gov/42165793/). *Neuro Endocrinol Lett*. [Epidemiology / Natural History]
Cerar A (2025). [PMID: 41301866](https://pubmed.ncbi.nlm.nih.gov/41301866/). *Biomedicines*. [Epidemiology / Natural History]
Lv Z (2025). [PMID: 40625854](https://pubmed.ncbi.nlm.nih.gov/40625854/). *Eur Heart J Case Rep*. [Case Report / Case Series]
He P (2025). [PMID: 41213470](https://pubmed.ncbi.nlm.nih.gov/41213470/). *Eur J Med Genet*. [Review / Meta-Analysis]
Bahout M (2025). [PMID: 39448255](https://pubmed.ncbi.nlm.nih.gov/39448255/). *J Neurol Neurosurg Psychiatry*. [Epidemiology / Natural History]
AI-curated news mentioning left ventricular noncompaction 7
Updated Mar 27, 2026
A recent study highlights a rare presentation of left ventricular noncompaction cardiomyopathy, identified through acute decompensated heart failure. This discovery may enhance understanding and diagnosis of this uncommon cardiac condition.
A recent case series published in PubMed explores surgical management techniques for left ventricular masses, emphasizing ventricular-sparing approaches. This research contributes to the understanding of cardiac surgery options for rare cardiac conditions.
A recent study published in PubMed discusses a case of left ventricular intimal sarcoma that was initially misidentified as a benign mass. This highlights the importance of accurate diagnosis in rare cardiac tumors.