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The phase of chronic myeloid leukemia following the chronic phase (leukemia, myeloid, chronic-phase), where there are increased systemic symptoms, worsening cytopenias, and refractory leukocytosis.
Biomarker and diagnostic research for leukemia, myeloid, accelerated-phase has been reported in the published literature.
19 clinical trials registered, 8 recruiting. Interventions under study include drug therapy, other interventions, biologic therapy, and procedural interventions. Pipeline includes 9 PHASE2, 5 PHASE1, 1 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06453902](https://clinicaltrials.gov/study/NCT06453902) | TGRX-678 Chinese Phase II in Chronic Myelogenous Leukemia (CML) Patients | PHASE2 | Shenzhen TargetRx Co., Ltd. | RECRUITING |
[NCT05794880](https://clinicaltrials.gov/study/NCT05794880) | MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing | NA | Medical College of Wisconsin | RECRUITING |
[NCT02727803](https://clinicaltrials.gov/study/NCT02727803) | Personalized NK Cell Therapy in CBT | PHASE2 | M.D. Anderson Cancer Center | RECRUITING |
[NCT07020533](https://clinicaltrials.gov/study/NCT07020533) | A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant | PHASE1 | City of Hope Medical Center | RECRUITING |
[NCT01137825](https://clinicaltrials.gov/study/NCT01137825) | Registry of Older Patients With Cancer | — | UNC Lineberger Comprehensive Cancer Center | RECRUITING |
68 publications have been identified in PubMed for leukemia, myeloid, accelerated-phase. Research spans Review / Meta-Analysis (28%), Epidemiology / Natural History (19%), and Case Report / Case Series (18%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 19 | 28% |
Disease patterns and progression | 13 | 19% |
Patient case studies | 12 | 18% |
Clinical study results | 12 | 18% |
Laboratory research | 6 | 9% |
Testing and diagnosis research | 5 |
Cracchiolo MJ (2026). [PMID: 42126094](https://pubmed.ncbi.nlm.nih.gov/42126094/). *Eur J Haematol*. [Review / Meta-Analysis]
Chen EC (2026). [PMID: 42189880](https://pubmed.ncbi.nlm.nih.gov/42189880/). *Clin Cancer Res*. [Clinical Trial Publication]
Achar RK (2026). [PMID: 42156280](https://pubmed.ncbi.nlm.nih.gov/42156280/). *Semin Hematol*. [Review / Meta-Analysis]
Yuan M (2026). [PMID: 41098110](https://pubmed.ncbi.nlm.nih.gov/41098110/). *Haematologica*. [Clinical Trial Publication]
Lee S (2026). [PMID: 42174310](https://pubmed.ncbi.nlm.nih.gov/42174310/). *Ann Hematol*. [Epidemiology / Natural History]
Zarama-Valenzuela Á (2026). [PMID: 42011407](https://pubmed.ncbi.nlm.nih.gov/42011407/). *Rare Tumors*. [Case Report / Case Series]
Schenk T (2026). [PMID: 41535610](https://pubmed.ncbi.nlm.nih.gov/41535610/). *Ann Hematol*. [Epidemiology / Natural History]
Emiliano EG (2026). [PMID: 42142415](https://pubmed.ncbi.nlm.nih.gov/42142415/). *Hematol Transfus Cell Ther*. [Epidemiology / Natural History]
Chauhan P (2026). [PMID: 41936271](https://pubmed.ncbi.nlm.nih.gov/41936271/). *Curr Res Transl Med*. [Diagnostic / Biomarker]
Mauro MJ (2026). [PMID: 41329950](https://pubmed.ncbi.nlm.nih.gov/41329950/). *Blood*. [Review / Meta-Analysis]
Data assembled from 3 of 12 sources · Last updated Oct 4, 2026, 12:22 AM UTC
New treatment approaches | 1 | 1% |