LMNA-related cardiocutaneous progeria syndrome is a rare genetic condition that causes premature aging. People with this condition develop skin changes in adulthood such as thinning and graying of scalp hair, loss of subcutaneous fat, and tightening of the skin, which lead to an aged appearance. Additionally, cardiovascular issues including accelerated atherosclerosis, calcific valve disease, and cardiomyopathy are common, and there is an early loss of eyebrows and eyelashes during childhood. There is also a noted predisposition to develop malignancies.

Common symptoms include visible skin changes like thinning, graying hair, loss of fat, and tightening of the skin, which contribute to an aged appearance. People with this condition may also experience loss of eyebrows and eyelashes in childhood, along with significant heart-related issues such as atherosclerosis, calcific valve disease, and cardiomyopathy.

LMNA-related cardiocutaneous progeria syndrome is a genetic disorder. The name indicates that changes in the LMNA gene play a role in the condition, leading to premature aging and cardiovascular complications. Detailed information about other genetic or risk factors is not available.