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loose anagen syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

loose anagen syndrome

MONDO:0010908

Also known as:loose anagen hair syndrome

Overview

Loose anagen syndrome is a rare benign hair disorder affecting predominantly blond females in childhood and characterized by the presence of hair that can be easily and painlessly pulled out. Most of the hair is in the anagen phase and lacks an external epithelial sheath. Hair grows back quickly and the condition improves spontaneously with aging. Loose anagen hair can be associated with other anomalies, such as coloboma.

GeneticsAutosomal dominant

ResearchLimited published research (7 articles)

Clinical Presentation

Features include very common findings: Abnormal hair morphology and Abnormal hair whorl; and common findings: Iris coloboma. 6 total HPO annotations.

Explore clinical features

Prognosis

Phenotype severity distribution: 2 very common features, 1 common feature.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for loose anagen syndrome.

10 publications have been identified in PubMed for loose anagen syndrome. Kisho has analyzed 7 by research type. Research spans Case Report / Case Series (43%), Gene Therapy / Novel Therapeutics (29%), and Other (14%).

Recent Publications

Dehghan Y (2026). [PMID: 41626099](https://pubmed.ncbi.nlm.nih.gov/41626099/). *Clinical case reports*. [Case Report / Case Series]
Gana S (2025). [PMID: 40586991](https://pubmed.ncbi.nlm.nih.gov/40586991/). *Neurogenetics*. [Case Report / Case Series]
Melo M (2025). [PMID: 40814173](https://pubmed.ncbi.nlm.nih.gov/40814173/). *HGG Adv*. [Gene Therapy / Novel Therapeutics]
Wang XO (2025). [PMID: 40090919](https://pubmed.ncbi.nlm.nih.gov/40090919/). *Zhonghua Er Ke Za Zhi*. [Epidemiology / Natural History]
Gupta I (2025). [PMID: 40654546](https://pubmed.ncbi.nlm.nih.gov/40654546/). *Int J Trichology*. [Other]

Data assembled from 5 of 12 sources · Last updated Oct 3, 2026, 11:03 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:600628

Orphanet

European rare disease database

Orphanet:168

GARD

Genetic and Rare Diseases Info Center

GARD:3287

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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loose anagen syndrome

Overview

Clinical Presentation

Explore clinical features

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team