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A localized non-invasive adenocarcinoma of the lung measuring 3 cm or less. It is characterized by a pure lepidic growth pattern and the lack of stromal, vascular, or pleural invasion.
Biomarker and diagnostic research for lung adenocarcinoma in situ has been reported in the published literature.
3 clinical trials registered, 1 recruiting. Interventions under study include procedural interventions, drug therapy, other interventions, and biologic therapy. Pipeline includes 1 PHASE2, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
17 publications have been identified in PubMed for lung adenocarcinoma in situ. Research spans Case Report / Case Series (41%), Basic Science / Preclinical (18%), and Diagnostic / Biomarker (12%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 7 |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 7:58 AM UTC
41%
Laboratory research | 3 | 18% |
Testing and diagnosis research | 2 | 12% |
Research summaries | 2 | 12% |
Disease patterns and progression | 2 | 12% |
Clinical study results | 1 | 6% |
Dong N (2026). [PMID: 42205745](https://pubmed.ncbi.nlm.nih.gov/42205745/). *Front Oncol*. [Basic Science / Preclinical]
Fan C (2026). [PMID: 42222393](https://pubmed.ncbi.nlm.nih.gov/42222393/). *Front Oncol*. [Case Report / Case Series]
Li Y (2026). [PMID: 41629559](https://pubmed.ncbi.nlm.nih.gov/41629559/). *Cell Res*. [Basic Science / Preclinical]
Chen K (2025). [PMID: 39959263](https://pubmed.ncbi.nlm.nih.gov/39959263/). *World J Diabetes*. [Epidemiology / Natural History]
Oka N (2025). [PMID: 40865920](https://pubmed.ncbi.nlm.nih.gov/40865920/). *Mod Pathol*. [Case Report / Case Series]
Meijer-Jorna LB (2025). [PMID: 40419275](https://pubmed.ncbi.nlm.nih.gov/40419275/). *Arch Pathol Lab Med*. [Diagnostic / Biomarker]
Tang S (2025). [PMID: 40894277](https://pubmed.ncbi.nlm.nih.gov/40894277/). *Curr Urol*. [Case Report / Case Series]
Chae YK (2025). [PMID: 39487975](https://pubmed.ncbi.nlm.nih.gov/39487975/). *Oncologist*. [Review / Meta-Analysis]
Copeland J (2025). [PMID: 40943890](https://pubmed.ncbi.nlm.nih.gov/40943890/). *J Clin Med*. [Epidemiology / Natural History]
Huang Y (2025). [PMID: 41430026](https://pubmed.ncbi.nlm.nih.gov/41430026/). *Discov Oncol*. [Case Report / Case Series]
AI-curated news mentioning lung adenocarcinoma in situ
Updated Aug 28, 2026
A rare case study highlights tumor-to-tumor metastasis, where clear cell renal cell carcinoma metastasizes into lung adenocarcinoma. This finding contributes to the understanding of cancer behavior and potential treatment implications.
This publication presents two case reports of advanced lung adenocarcinoma with complex genetic alterations, including EGFR exon 19 deletion, T790M mutation, STRN::ALK fusion, and EGFR kinase domain duplication. The findings contribute to the understanding of peritoneal metastasis in this cancer subtype.
A case report details an autopsy-confirmed giant pleural hematoma resulting from spontaneous hemothorax in a patient with ALK-rearranged and TP53-mutant lung adenocarcinoma. This study contributes to the understanding of complications associated with specific genetic mutations in lung cancer.