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A frequent form of late-onset, primary lymphedema characterized by lower limb lymphedema typically developing during puberty.
Features include sometimes findings: Cleft palate, Facial edema, and Yellow nails. 5 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Head and neck | 2 | Cleft palate, Facial edema |
Skin |
Biomarker and diagnostic research for lymphatic malformation 5 has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
1 clinical trial registered. Pipeline includes 1 NA.
220 publications have been identified in PubMed for lymphatic malformation 5. Research spans Case Report / Case Series (24%), Basic Science / Preclinical (21%), and Clinical Trial Publication (17%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 52 | 24% |
Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 1:58 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
2
Predominantly lower limb lymphedema, Yellow nails |
Arms and legs | 1 | Predominantly lower limb lymphedema |
46 |
21% |
Clinical study results | 38 | 17% |
Research summaries | 33 | 15% |
Disease patterns and progression | 30 | 14% |
Testing and diagnosis research | 13 | 6% |
New treatment approaches | 6 | 3% |
Other research | 2 | 1% |
Sisk BA (2026). [PMID: 41185141](https://pubmed.ncbi.nlm.nih.gov/41185141/). *Pediatr Blood Cancer*. [Other]
Mashrah HT (2026). [PMID: 42201813](https://pubmed.ncbi.nlm.nih.gov/42201813/). *J Craniofac Surg*. [Case Report / Case Series]
Singh M (2026). [PMID: 42241350](https://pubmed.ncbi.nlm.nih.gov/42241350/). *Indian J Ophthalmol*. [Clinical Trial Publication]
Jovanovic P (2026). [PMID: 41446572](https://pubmed.ncbi.nlm.nih.gov/41446572/). *Case Rep Gastroenterol*. [Case Report / Case Series]
Williamson A (2026). [PMID: 40095972](https://pubmed.ncbi.nlm.nih.gov/40095972/). *Cleft Palate Craniofac J*. [Epidemiology / Natural History]
Tian Z (2026). [PMID: 41105096](https://pubmed.ncbi.nlm.nih.gov/41105096/). *J Craniofac Surg*. [Case Report / Case Series]
Liao Y (2026). [PMID: 41621846](https://pubmed.ncbi.nlm.nih.gov/41621846/). *Zhonghua Yi Xue Yi Chuan Xue Za Zhi*. [Review / Meta-Analysis]
Fujisawa K (2026). [PMID: 41510600](https://pubmed.ncbi.nlm.nih.gov/41510600/). *Microsurgery*. [Case Report / Case Series]
Han WT (2026). [PMID: 41834198](https://pubmed.ncbi.nlm.nih.gov/41834198/). *Zhonghua Er Ke Za Zhi*. [Basic Science / Preclinical]
Han T (2026). [PMID: 42194110](https://pubmed.ncbi.nlm.nih.gov/42194110/). *Children (Basel)*. [Clinical Trial Publication]