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Malignant atrophic papulosis (MAP) is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and a surrounding teleangiectatic rim. Systemic lesions may affect the gastrointestinal tract and the central nervous system (CNS) and are potentially lethal.
Features include: Pleural effusion, Stroke, Constrictive pericarditis, and Gastrointestinal infarctions and 3 more.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Heart and blood vessels | 2 | Stroke, Constrictive pericarditis |
Digestive system |
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
1 clinical trial registered, 1 recruiting. Interventions under study include drug therapy. Pipeline includes 1 PHASE2. Research is primarily sponsored by academic and government institutions.
42 publications have been identified in PubMed for malignant atrophic papulosis. Research spans Case Report / Case Series (76%), Review / Meta-Analysis (13%), and Gene Therapy / Novel Therapeutics (5%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 29 |
Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 8:51 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
2
Gastrointestinal infarctions, Gastrointestinal hemorrhage |
Lungs and breathing | 1 | Pleural effusion |
Brain and nerves | 1 | Stroke |
Eyes | 1 | Abnormal conjunctiva morphology |
Skin | 1 | Papule |
Research summaries | 5 | 13% |
New treatment approaches | 2 | 5% |
Other research | 1 | 3% |
Laboratory research | 1 | 3% |
Alshehri MA (2026). [PMID: 42170366](https://pubmed.ncbi.nlm.nih.gov/42170366/). *Cureus*. [Case Report / Case Series]
Meena A (2026). [PMID: 41530906](https://pubmed.ncbi.nlm.nih.gov/41530906/). *Clin Exp Dermatol*. [Case Report / Case Series]
Barbé A (2026). [PMID: 41858548](https://pubmed.ncbi.nlm.nih.gov/41858548/). *Am J Ophthalmol Case Rep*. [Case Report / Case Series]
Silva V (2026). [PMID: 41657526](https://pubmed.ncbi.nlm.nih.gov/41657526/). *JAAD Case Rep*. [Case Report / Case Series]
Magro CM (2026). [PMID: 41474865](https://pubmed.ncbi.nlm.nih.gov/41474865/). *Am J Dermatopathol*. [Case Report / Case Series]
Garg S (2026). [PMID: 41483502](https://pubmed.ncbi.nlm.nih.gov/41483502/). *An Bras Dermatol*. [Case Report / Case Series]
Ilyasova A (2026). [PMID: 41717716](https://pubmed.ncbi.nlm.nih.gov/41717716/). *J Investig Med High Impact Case Rep*. [Case Report / Case Series]
Zhong R (2026). [PMID: 41554475](https://pubmed.ncbi.nlm.nih.gov/41554475/). *J Gastrointest Surg*. [Case Report / Case Series]
Tsai YT (2026). [PMID: 41854241](https://pubmed.ncbi.nlm.nih.gov/41854241/). *J Dtsch Dermatol Ges*. [Case Report / Case Series]
Garbayo-Salmons P (2026). [PMID: 41352596](https://pubmed.ncbi.nlm.nih.gov/41352596/). *Actas Dermosifiliogr*. [Case Report / Case Series]
AI-curated news mentioning malignant atrophic papulosis
Updated Jul 27, 2026
A recent study published in PubMed explores solitary lesions resembling atrophic papulosis in early childhood. This research contributes to the understanding of skin manifestations in pediatric patients.
A recent study published in PubMed explores ocular multimodal imaging in a patient with malignant atrophic papulosis, also known as Degos disease. This research contributes to the understanding of the disease's ocular manifestations.