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malignant hyperthermia of anesthesia - Clinical Profile, Treatments & Trials | Kisho | Kisho

Rare Disease

malignant hyperthermia of anesthesia

MONDO:0018493

Also known as:anaesthesia related hyperthermiaanesthesia related hyperthermiahyperthermia of anaesthesia

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Overview

A pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gasses such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, to stresses such as vigorous exercise and heat.

Treatments2 FDA approved

Clinical Trials2 registered · 1 recruiting

Patient Orgs1 organizations · Malignant Hyperthermia Association of the United States

Diagnosis

Biomarker and diagnostic research for malignant hyperthermia of anesthesia has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

1 FDA-approved treatment is available for malignant hyperthermia of anesthesia, including DANTROLENE SODIUM (DANTRIUM, approved 1979).

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered, 1 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.

212 publications have been identified in PubMed for malignant hyperthermia of anesthesia. Kisho has analyzed 121 by research type. Research spans Case Report / Case Series (47%), Review / Meta-Analysis (15%), and Basic Science / Preclinical (14%).

Research Type	Count	% of Total
Patient case studies	57

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 11:13 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Patient Advocacy Groups

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Malignant Hyperthermia Association of the United StatesPrimary Focus

USWebsite ↗

Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.

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Medical References

External Resources

Orphanet

European rare disease database

Orphanet:423

GARD

Genetic and Rare Diseases Info Center

GARD:6964

Questions for Your Care Team

→What are the benefits and potential side effects of DANTRIUM for managing malignant hyperthermia of anesthesia?
→Are any of the 2 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→How can I connect with Malignant Hyperthermia Association of the United States and other patient organizations for support?

← Back to All Diseases

Kisho

malignant hyperthermia of anesthesia

Overview

Diagnosis

Treatment

Approved Therapies

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Adverse Event Profiles

Clinical Trials

Recent Publications

malignant hyperthermia of anesthesia

Overview

Diagnosis

Treatment

Approved Therapies

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Adverse Event Profiles

Clinical Trials

Recent Publications