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mast cell activation syndrome (MACS) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

mast cell activation syndrome

MONDO:0100004

Also known as:MACSdisorder of mast cell activation

Find Clinical TrialsTrials

Overview

A clinically defined disease states with a largely unknown morphological background. Acute mast cell activation (MCA) is commonly seen in allergic reactions and often leads to the clinical signs and symptoms of anaphylaxis. Severe or even life‐threatening MCA may occur when the burden of mast cells is high and/or these cells are in an hyperactivated state. Mastocytosis may be associated with mast cell activation syndrome (MCAS).

Clinical Trials2 registered · 1 recruiting

Diagnosis

Biomarker and diagnostic research for mast cell activation syndrome has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered, 1 recruiting. Interventions under study include other interventions. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.

172 publications have been identified in PubMed for mast cell activation syndrome. Kisho has analyzed 116 by research type. Research spans Review / Meta-Analysis (37%), Basic Science / Preclinical (22%), and Case Report / Case Series (16%).

Research Type	Count	% of Total
Research summaries	43

Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:14 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

GARD

Genetic and Rare Diseases Info Center

GARD:12981

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

mast cell activation syndrome

Overview

Diagnosis

Research Landscape

Medical References

External Resources

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Progress in mast cell activation syndrome: the global consensus-2 diagnostic criteria at six years.

mast cell activation syndrome

Overview

Diagnosis

Research Landscape

Medical References

External Resources

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Progress in mast cell activation syndrome: the global consensus-2 diagnostic criteria at six years.