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maternal hyperthermia induced birth defects - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

maternal hyperthermia induced birth defects

MONDO:0016378

Also known as:hyperthermia induced defects

Overview

Maternal hyperthermia induced birth defects is a rare maternal disease-related embryofetopathy characterized by variable developmental anomalies of the fetus due to teratogenic effect of elevated maternal body temperature (resulting from febrile illness or hot environment exposure). Reported developmental anomalies include neural tube defects (spina bifida, ecephalocele, anencephaly), cardiac defects (transposition of great vessels), urogenital defects (hypospadias), abdominal wall defects, cleft lip/palate, eye defects (cataract, coloboma) or various minor anomalies (e.g., bifid uvula, preauricular pit or tag). Consensus regarding cause-effect relationship has not been reached.

Patient Orgs1 organizations · Birth Defect Research for Children, Inc.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for maternal hyperthermia induced birth defects.

50 publications have been identified in PubMed for maternal hyperthermia induced birth defects. Research spans Basic Science / Preclinical (56%), Case Report / Case Series (18%), and Review / Meta-Analysis (14%).

Research Type	Count	% of Total
Laboratory research	28	56%

Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 5:04 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Patient Advocacy Groups

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Birth Defect Research for Children, Inc.Primary Focus

USWebsite ↗

Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.

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Medical References

External Resources

Orphanet

European rare disease database

Orphanet:2216

GARD

Genetic and Rare Diseases Info Center

GARD:2856

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→How can I connect with Birth Defect Research for Children, Inc. and other patient organizations for support?

← Back to All Diseases

Kisho

maternal hyperthermia induced birth defects

Overview

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

New Data Show Drinking While Pregnant Still a Problem

National Birth Defects Prevention Study Shows Assisted Reproductive Technology is Associated with an Increased Risk of Certain Birth Defects

National Birth Defects Prevention Study Finds Pre-pregnancy Diabetes Increases Risk for Multiple Types of Birth Defects

maternal hyperthermia induced birth defects

Overview

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

New Data Show Drinking While Pregnant Still a Problem

National Birth Defects Prevention Study Shows Assisted Reproductive Technology is Associated with an Increased Risk of Certain Birth Defects

National Birth Defects Prevention Study Finds Pre-pregnancy Diabetes Increases Risk for Multiple Types of Birth Defects