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Maternally inherited diabetes and deafness (MIDD) is a mitochondrial disorder characterized by maternally transmitted diabetes and sensorineural deafness.
Features include always present findings: Constriction of peripheral visual field; and sometimes findings: Ptosis and Heart muscle disease (cardiomyopathy). 14 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Ears | 3 | Abnormal vestibular function, Vertigo, Inner ear hearing loss (sensorineural hearing impairment) |
Biomarker and diagnostic research for maternally-inherited diabetes and deafness has been reported in the published literature.
Phenotype severity distribution: 1 always present feature.
1 clinical trial registered, 1 recruiting. Interventions under study include drug therapy. Pipeline includes 1 PHASE3. Research is primarily industry-sponsored.
63 publications have been identified in PubMed for maternally-inherited diabetes and deafness. Research spans Basic Science / Preclinical (29%), Case Report / Case Series (27%), and Review / Meta-Analysis (19%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 18 | 29% |
Data assembled from 6 of 12 sources · Last updated Sep 20, 2026, 5:51 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Brain and nerves
3 |
Seizure, Dysarthria, Unsteady gait |
Eyes | 3 | Pigmentary retinopathy, Ptosis, Retinal degeneration |
Heart and blood vessels | 1 | Heart muscle disease (cardiomyopathy) |
Hormones | 1 | Type II diabetes mellitus |
Patient case studies |
17 |
27% |
Research summaries | 12 | 19% |
Other research | 7 | 11% |
Disease patterns and progression | 5 | 8% |
Testing and diagnosis research | 4 | 6% |
Chen Y (2026). [PMID: 41679598](https://pubmed.ncbi.nlm.nih.gov/41679598/). *Diabetes Metab*. [Epidemiology / Natural History]
Reddy SB (2026). [PMID: 41992454](https://pubmed.ncbi.nlm.nih.gov/41992454/). *Ann Afr Med*. [Case Report / Case Series]
Huynh BC (2026). [PMID: 41845931](https://pubmed.ncbi.nlm.nih.gov/41845931/). *Ophthalmic Genet*. [Basic Science / Preclinical]
Oppenheimer KR (2026). [PMID: 41472381](https://pubmed.ncbi.nlm.nih.gov/41472381/). *J Clin Endocrinol Metab*. [Case Report / Case Series]
Picolos MK (2026). [PMID: 41668834](https://pubmed.ncbi.nlm.nih.gov/41668834/). *Eur J Case Rep Intern Med*. [Basic Science / Preclinical]
Finsterer J (2026). [PMID: 42144343](https://pubmed.ncbi.nlm.nih.gov/42144343/). *Rinsho Shinkeigaku*. [Basic Science / Preclinical]
Varga L (2026). [PMID: 41664274](https://pubmed.ncbi.nlm.nih.gov/41664274/). *Ear and hearing*. [Epidemiology / Natural History]
Plaza Enriquez L (2026). [PMID: 41621650](https://pubmed.ncbi.nlm.nih.gov/41621650/). *Endocr Pract*. [Basic Science / Preclinical]
Hayes E (2026). [PMID: 41999618](https://pubmed.ncbi.nlm.nih.gov/41999618/). *Horm Res Paediatr*. [Case Report / Case Series]
Kong X (2026). [PMID: 41887185](https://pubmed.ncbi.nlm.nih.gov/41887185/). *J Diabetes Res*. [Diagnostic / Biomarker]