McDonough syndrome is a rare condition that includes several birth-related issues. People with this syndrome show differences in the shape and appearance of their face, such as prominent eyebrows, a single line between the eyes (synophrys), strabismus (crossed eyes), large and forward-facing (anteverted) ears, a large nose, and issues with the way teeth line up. In addition, they may also experience delays in learning and movement. Another aspect of McDonough syndrome is the presence of heart defects, such as narrowing of the pulmonary valve (pulmonic stenosis), an opening between the heart chambers (atrial septal defect), or a condition called patent ductus arteriosus. There are also other physical findings including a sunken or protruding chest (pectus excavatum or carinatum), spinal curvature issues (kyphoscoliosis), weakness or separation in the abdominal muscles (diastasis recti), and in males, undescended testes (cryptorchidism).

Common signs of McDonough syndrome include facial differences such as prominent superciliary arcs (eyebrow ridges), synophrys, strabismus, large and anteverted ears, a large nose, and dental malocclusion. Other symptoms include delayed motor and mental development, congenital heart defects like pulmonic stenosis, patent ductus arteriosus, or atrial septal defect, as well as skeletal issues such as kyphoscoliosis and thorax deformities, and abdominal separation (diastasis recti). In males, cryptorchidism may be present.

Information about causes is currently limited for this condition.