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membranous glomerulonephritis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

membranous glomerulonephritis

MONDO:0005376

Also known as:membranous Glomerulonephropathymembranous nephropathy

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Overview

A slowly progressive inflammation of the glomeruli characterized by immune complex deposits at the glomerular basement membrane, resulting in a thickened membrane, and nephrotic syndrome.

TreatmentsNo approved treatments · 8 in pipeline

Clinical Trials63 registered · 28 recruiting

Diagnosis

Biomarker and diagnostic research for membranous glomerulonephritis has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for membranous glomerulonephritis. An additional 8 compounds hold orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for membranous glomerulonephritis, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for membranous glomerulonephritis. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

63 clinical trials registered, 28 recruiting. Interventions under study include drug therapy, other interventions, biologic therapy, and procedural interventions. Pipeline includes 4 PHASE4, 7 PHASE3, 20 PHASE2. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07404436](https://clinicaltrials.gov/study/NCT07404436)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 9:38 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→Are any of the 63 active clinical trials a good fit for my situation?
→With 8 compounds in the orphan drug pipeline, which are furthest along in development and which clinical trials should I be aware of?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	32	31%
Patient case studies	18	17%
Laboratory research	18	17%
Disease patterns and progression	12	12%
Clinical study results	10	10%
Testing and diagnosis research	9	9%
Other research	5	5%

membranous glomerulonephritis

Overview

Diagnosis

Treatment

Orphan Drug Designations

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

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