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meningococcal meningitis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

meningococcal meningitis

MONDO:0018059

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Overview

An acute bacterial disease caused by Neisseria meningitides that presents usually, but not always, with a rash (non blanching petechial or purpuric rash), progressively developing signs of meningitis (fever, vomiting, headache, photophobia, and neck stiffness) and later leading to confusion, delirium and drowsiness. Neck stiffness and photophobia are often absent in infants and young children who may manifest nonspecific signs such as irritability, inconsolable crying, poor feeding, and a bulging fontanel. Meningococcal meningitis may also present as part of early or late onset sepsis in neonates. The disease is potentially fatal. Surviving patients may develop neurological sequelae that include sensorineural hearing loss, seizures, spasticity, attention deficits and intellectual disability.

Clinical Trials6 registered · 1 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Fever, Increased CSF protein concentration, Hypoglycorrhachia, and CSF pleocytosis and others; and common findings: Photophobia, Petechiae, Skin rash, and Anorexia and others. 35 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	7	Nuchal rigidity, Headache, Irritability

Diagnosis

Biomarker and diagnostic research for meningococcal meningitis has been reported in the published literature.

Prognosis

Phenotype severity distribution: 6 very common features, 9 common features.

Estimated prevalence: 1-9 in 100,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

6 clinical trials registered, 1 recruiting. Interventions under study include biologic therapy. Pipeline includes 1 PHASE4, 3 PHASE3, 1 PHASE2. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06700148](https://clinicaltrials.gov/study/NCT06700148)

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 4:29 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:33475

GARD

Genetic and Rare Diseases Info Center

GARD:18809

Questions for Your Care Team

→Are any of the 6 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Patient case studies	21	32%
Disease patterns and progression	19	29%
Laboratory research	12	18%
Research summaries	7	11%
Testing and diagnosis research	4	6%
New treatment approaches	2	3%
Clinical study results	1	2%

Kisho

meningococcal meningitis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

meningococcal meningitis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications