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methemoglobinemia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

methemoglobinemia

MONDO:0001117

Also known as:methemoglobinemias

Overview

An inherited or acquired condition characterized by abnormally increased levels of methemoglobin in the blood.

TreatmentsNo approved treatments · 1 in pipeline

Diagnosis

Biomarker and diagnostic research for methemoglobinemia has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for methemoglobinemia. An additional 1 compound holds orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for methemoglobinemia, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for methemoglobinemia. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for methemoglobinemia.

240 publications have been identified in PubMed for methemoglobinemia. Research spans Case Report / Case Series (67%), Review / Meta-Analysis (10%), and Epidemiology / Natural History (9%).

Research Type	Count	% of Total
Patient case studies	161	67%

Data assembled from 3 of 12 sources · Last updated Oct 3, 2026, 5:08 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→What is the current development status of methylene blue, and when might it become available?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

methemoglobinemia

Overview

Diagnosis

Treatment

Orphan Drug Designations

Research Landscape

Medical References

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

methemoglobinemia

Overview

Diagnosis

Treatment

Orphan Drug Designations

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications