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Diabetes mellitus that is caused by mutations in a single gene.
Biomarker and diagnostic research for monogenic diabetes has been reported in the published literature.
8 clinical trials registered, 5 recruiting. Interventions under study include other interventions and drug therapy. Pipeline includes 1 PHASE2, 2 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06478121](https://clinicaltrials.gov/study/NCT06478121) |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 1:48 PM UTC
European rare disease database
Understanding Beta Cell Disorders Through the Study of Rare Genotypes (ENDURE)
— |
University of Exeter |
RECRUITING |
[NCT03988764](https://clinicaltrials.gov/study/NCT03988764) | Monogenic Diabetes Misdiagnosed as Type 1 | — | McGill University Health Centre/Research Institute of the McGill University Health Centre | UNKNOWN |
[NCT06746610](https://clinicaltrials.gov/study/NCT06746610) | Screening and Molecular Diagnosis-based Individualized Precision Management of Monogenic Diabetes | NA | Tianjin Medical University General Hospital | RECRUITING |
[NCT05586594](https://clinicaltrials.gov/study/NCT05586594) | Identifying Maturity-onset Diabetes of the Young in Emirati Patients | NA | United Arab Emirates University | UNKNOWN |
[NCT07492004](https://clinicaltrials.gov/study/NCT07492004) | China Monogenic Diabetes Registry | — | Tianjin Medical University General Hospital | RECRUITING |
281 publications have been identified in PubMed for monogenic diabetes. Kisho has analyzed 213 by research type. Research spans Review / Meta-Analysis (25%), Basic Science / Preclinical (21%), and Case Report / Case Series (20%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 53 | 25% |
Laboratory research | 44 | 21% |
Patient case studies | 43 | 20% |
Disease patterns and progression | 32 | 15% |
Testing and diagnosis research | 27 | 13% |
Other research | 6 | 3% |
Clinical study results | 6 | 3% |
New treatment approaches | 2 | 1% |
Hoffman LS (2026). [PMID: 30422495](https://pubmed.ncbi.nlm.nih.gov/30422495/). *Unknown Journal*. [Epidemiology / Natural History]
Hassan SS (2026). [PMID: 41275391](https://pubmed.ncbi.nlm.nih.gov/41275391/). *J Pediatr Endocrinol Metab*. [Epidemiology / Natural History]
Louvet I (2026). [PMID: 42100870](https://pubmed.ncbi.nlm.nih.gov/42100870/). *JCI Insight*. [Basic Science / Preclinical]
Yoshiji S (2026). [PMID: 40853921](https://pubmed.ncbi.nlm.nih.gov/40853921/). *The Journal of clinical endocrinology and metabolism*. [Diagnostic / Biomarker]
Harreiter J (2026). [PMID: 42162460](https://pubmed.ncbi.nlm.nih.gov/42162460/). *Wien Klin Wochenschr*. [Review / Meta-Analysis]
Sun S (2026). [PMID: 41547438](https://pubmed.ncbi.nlm.nih.gov/41547438/). *Diabetes Metab*. [Diagnostic / Biomarker]
Asamoah A (2026). [PMID: 41751598](https://pubmed.ncbi.nlm.nih.gov/41751598/). *Genes*. [Review / Meta-Analysis]
Grancini V (2026). [PMID: 42040600](https://pubmed.ncbi.nlm.nih.gov/42040600/). *Front Med (Lausanne)*. [Other]
Fatani TH (2026). [PMID: 41772505](https://pubmed.ncbi.nlm.nih.gov/41772505/). *BMC Pediatr*. [Case Report / Case Series]
Giannopoulou EZ (2026). [PMID: 41961439](https://pubmed.ncbi.nlm.nih.gov/41961439/). *Mol Cell Pediatr*. [Basic Science / Preclinical]
AI-curated news mentioning monogenic diabetes
Updated Aug 6, 2026
A national study investigates the glycemic and renal effects of SGLT2 inhibitors in patients with monogenic diabetes. The findings contribute to understanding treatment efficacy in this rare patient population.
A recent study highlights the presence of monogenic kidney disease and monogenic diabetes in patients at renal clinics who were previously diagnosed with non-genetic conditions. This finding suggests the need for genetic testing in these patients to identify underlying genetic causes.
A study highlights the effectiveness of short-read next-generation sequencing (NGS) in diagnosing monogenic diabetes among Polish patients. This research could enhance molecular testing accuracy for this rare condition.