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A sensation of discomfort that results from a discordant relationship between visualized movement and any movement sensed by the vestibular system, which is characterized by dizziness, nausea, and vomiting.
Features include: Nervous system problems (abnormality of the nervous system).
Organ System | Phenotype Count | Example Features |
|---|---|---|
Brain and nerves | 1 | Nervous system problems (abnormality of the nervous system) |
Biomarker and diagnostic research for motion sickness has been reported in the published literature.
1 FDA-approved treatment is available for motion sickness, including SCOPOLAMINE (TRANSDERM SCOP, approved 1979).
Brand Name | Generic Name | Mechanism | Approved | Market Status |
|---|---|---|---|---|
9 clinical trials registered, 3 recruiting. Interventions under study include other interventions, medical devices, and drug therapy. Pipeline includes 1 PHASE3, 2 PHASE2, 4 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06892340](https://clinicaltrials.gov/study/NCT06892340) |
Data assembled from 6 of 12 sources · Last updated Sep 17, 2026, 9:37 PM UTC
Online Mendelian Inheritance in Man
SCOPOLAMINE |
— |
1979 |
Available |
Gene therapy approaches for motion sickness have been reported in the published literature.
9 trials found
Evaluation of a Device to Reduce Motion Sickness and Spatial Disorientation |
NA |
59th Medical Wing |
RECRUITING |
[NCT05622344](https://clinicaltrials.gov/study/NCT05622344) | StableEyes With Active Neurofeedback | NA | Johns Hopkins University | RECRUITING |
[NCT05852730](https://clinicaltrials.gov/study/NCT05852730) | Combination of Intranasal Scopolamine and Sensory Augmentation to Mitigate G-transition Induced Motion Sickness and Enhance Sensorimotor Performance | PHASE2 | Repurposed Therapeutics, Inc. | RECRUITING |
[NCT07297862](https://clinicaltrials.gov/study/NCT07297862) | Virtual Reality Sickness Questionnaire: Psychometrics in Stroke Patients | — | Abant Izzet Baysal University | ENROLLING_BY_INVITATION |
[NCT05886660](https://clinicaltrials.gov/study/NCT05886660) | Combination of Intranasal Scopolamine and Sensory Augmentation to Mitigate G-transition Induced Motion Sickness and Enhance Sensorimotor Performance | PHASE2 | Repurposed Therapeutics, Inc. | UNKNOWN |
245 publications have been identified in PubMed for motion sickness. Kisho has analyzed 142 by research type. Research spans Basic Science / Preclinical (44%), Review / Meta-Analysis (19%), and Clinical Trial Publication (15%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 63 | 44% |
Research summaries | 27 | 19% |
Clinical study results | 22 | 15% |
Disease patterns and progression | 17 | 12% |
Testing and diagnosis research | 8 | 6% |
New treatment approaches | 3 | 2% |
Other research | 1 | 1% |
Patient case studies | 1 | 1% |
Zhao J (2026). [PMID: 40237219](https://pubmed.ncbi.nlm.nih.gov/40237219/). *Acta oto-laryngologica*. [Clinical Trial Publication]
Emond W (2026). [PMID: 41205437](https://pubmed.ncbi.nlm.nih.gov/41205437/). *Appl Ergon*. [Epidemiology / Natural History]
Tajdari F (2026). [PMID: 41830678](https://pubmed.ncbi.nlm.nih.gov/41830678/). *Appl Ergon*. [Case Report / Case Series]
Hughes CK (2026). [PMID: 41774616](https://pubmed.ncbi.nlm.nih.gov/41774616/). *Otolaryngol Head Neck Surg*. [Epidemiology / Natural History]
Callejas Pastor CA (2026). [PMID: 42062472](https://pubmed.ncbi.nlm.nih.gov/42062472/). *Sci Rep*. [Epidemiology / Natural History]
Lee A (2026). [PMID: 41945307](https://pubmed.ncbi.nlm.nih.gov/41945307/). *Drugs*. [Epidemiology / Natural History]
Manzari L (2026). [PMID: 42019191](https://pubmed.ncbi.nlm.nih.gov/42019191/). *Am J Otolaryngol*. [Review / Meta-Analysis]
Louvenberg S (2026). [PMID: 41849853](https://pubmed.ncbi.nlm.nih.gov/41849853/). *Appl Ergon*. [Diagnostic / Biomarker]
Sicari V (2026). [PMID: 30252266](https://pubmed.ncbi.nlm.nih.gov/30252266/). *Unknown Journal*. [Gene Therapy / Novel Therapeutics]
Rust HM (2026). [PMID: 41760396](https://pubmed.ncbi.nlm.nih.gov/41760396/). *Journal of neurology, neurosurgery, and psychiatry*. [Basic Science / Preclinical]