MRCS syndrome is a rare genetic retinal dystrophy that affects both eyes. People with this condition have abnormally small corneas (microcornea), problems with the retina (rod-cone dystrophy), cataracts, and a bulging of the back of the eye (posterior staphyloma). This condition does not involve other body systems. Night blindness is often the first sign, and as time goes on, the vision may get worse. The condition can lead to very poor vision, with some people experiencing little to no light perception, while others may see as well as 20/400. Associated eye issues such as nystagmus, strabismus, and astigmatism, as well as angle closure glaucoma, may also be observed.

Common symptoms include difficulty seeing in low light or at night (night blindness) and other visual challenges like nystagmus (uncontrolled eye movements), strabismus (misaligned eyes), and astigmatism (blurry vision). Cataracts and progressive vision loss, along with potential angle closure glaucoma, have also been noted in people with this condition.

MRCS syndrome is a genetic condition, meaning it is passed down through families and is linked to changes in genes. However, specific genes have not yet been identified for this condition.