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multifocal lymphangioendotheliomatosis-thrombocytopenia syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

multifocal lymphangioendotheliomatosis-thrombocytopenia syndrome

MONDO:0018735

Also known as:DKFZp434L132MALT1 wt alleleMLT

Overview

Human MALT1 wild-type allele is located in the vicinity of 18q21 and is approximately 79 kb in length. This allele, which encodes mucosa associated lymphoid tissue lymphoma translocation gene 1 protein, plays a role in the modulation of the nuclear factor kappa B complex signaling cascade. The gene is involved in a chromosomal translocation t(11;18)(q21;q21) with the BIRC2 gene in mucosa-associated lymphoid tissue lymphomas.

Diagnosis

Biomarker and diagnostic research for multifocal lymphangioendotheliomatosis-thrombocytopenia syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for multifocal lymphangioendotheliomatosis-thrombocytopenia syndrome.

200 publications have been identified in PubMed for multifocal lymphangioendotheliomatosis-thrombocytopenia syndrome. Kisho has analyzed 60 by research type. Research spans Review / Meta-Analysis (65%), Epidemiology / Natural History (13%), and Case Report / Case Series (10%).

Research Type	Count	% of Total
Research summaries	39	65%

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 4:55 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:464321

GARD

Genetic and Rare Diseases Info Center

GARD:10467

Questions for Your Care Team

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multifocal lymphangioendotheliomatosis-thrombocytopenia syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications