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myalgia-eosinophilia syndrome associated with tryptophan - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

myalgia-eosinophilia syndrome associated with tryptophan

MONDO:0016822

Overview

A rare systemic disease characterized by severe myalgia and peripheral eosinophilia associated with tryptophan dietary supplementation. The symptoms do not subside after tryptophan discontinuation. Clinical presentation includes muscle tenderness and cramps, fatigue, weakness, paresthesia, peripheral edema, arthralgia, dyspnea, skin rash, dry mouth, and development of scleroderma-like skin abnormalities.

ResearchLimited published research (2 articles)

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for myalgia-eosinophilia syndrome associated with tryptophan.

2 publications have been identified in PubMed for myalgia-eosinophilia syndrome associated with tryptophan. Research spans Review / Meta-Analysis (50%) and Case Report / Case Series (50%).

Recent Publications

Ihssan HH (2025). [PMID: 39881778](https://pubmed.ncbi.nlm.nih.gov/39881778/). *Radiol Case Rep*. [Case Report / Case Series]
Dang Y (2025). [PMID: 41137258](https://pubmed.ncbi.nlm.nih.gov/41137258/). *Medicine (Baltimore)*. [Review / Meta-Analysis]

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:39 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:2582

GARD

Genetic and Rare Diseases Info Center

GARD:18775

Questions for Your Care Team

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myalgia-eosinophilia syndrome associated with tryptophan

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team