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neonatal alloimmune neutropenia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

neonatal alloimmune neutropenia

MONDO:0018739

Overview

A rare acquired neutropenia characterized by isolated neutropenia in a newborn due to maternal alloimmunization against human neutrophil antigens (HNA) inherited from the father and present on fetal neutrophils, and subsequent increased breakdown of the latter. The condition is self-limiting and resolves after several weeks. It usually presents with only mild bacterial infections or may even be asymptomatic, although severe forms with sepsis and fatal outcome have also been reported.

ResearchLimited published research (4 articles)

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for neonatal alloimmune neutropenia.

4 publications have been identified in PubMed for neonatal alloimmune neutropenia. Research spans Case Report / Case Series (50%), Review / Meta-Analysis (25%), and Epidemiology / Natural History (25%).

Recent Publications

González-Pérez C (2026). [PMID: 41881485](https://pubmed.ncbi.nlm.nih.gov/41881485/). *BMJ case reports*. [Case Report / Case Series]
Nogueira-Silva LC (2025). [PMID: 41046495](https://pubmed.ncbi.nlm.nih.gov/41046495/). *Transfusion*. [Epidemiology / Natural History]
Martins JO (2024). [PMID: 38597364](https://pubmed.ncbi.nlm.nih.gov/38597364/). *Vox sanguinis*. [Case Report / Case Series]
Magdesian KG (2024). [PMID: 38852013](https://pubmed.ncbi.nlm.nih.gov/38852013/). *The Veterinary clinics of North America. Equine practice*. [Review / Meta-Analysis]

Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:26 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:464370

GARD

Genetic and Rare Diseases Info Center

GARD:21929

Questions for Your Care Team

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neonatal alloimmune neutropenia

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team