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neonatal myasthenia gravis - Clinical Profile, Treatments & Trials | Kisho | Kisho

Rare Disease

neonatal myasthenia gravis

MONDO:0006866

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Overview

A disorder of neuromuscular transmission that occurs in a minority of newborns born to women with myasthenia gravis. Clinical features are usually present at birth or develop in the first 3 days of life and consist of hypotonia and impaired respiratory, suck, and swallowing abilities. This condition is associated with the passive transfer of acetylcholine receptor antibodies through the placenta. In the majority of infants the myasthenic weakness resolves (i.e., transient neonatal myasthenia gravis) although this disorder may rarely continue beyond the neonatal period (i.e., persistent neonatal myasthenia gravis). (From Menkes, Textbook of Child Neurology, 5th ed, p823; Neurology 1997 Jan;48(1):50-4)

Treatments1 FDA approved

Clinical Trials1 registered · 1 recruiting

ResearchLimited published research (5 articles)

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

1 FDA-approved treatment is available for neonatal myasthenia gravis, including PYRIDOSTIGMINE BROMIDE (PYRIDOSTIGMINE BROMIDE, approved 1965).

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered, 1 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.

5 publications have been identified in PubMed for neonatal myasthenia gravis. Research spans Review / Meta-Analysis (60%), Case Report / Case Series (20%), and Epidemiology / Natural History (20%).

Recent Publications

Miegel L (2026). [PMID: 41787190](https://pubmed.ncbi.nlm.nih.gov/41787190/). *J Neurol*. [Review / Meta-Analysis]
Gerede A (2026). [PMID: 41897632](https://pubmed.ncbi.nlm.nih.gov/41897632/). *Diagnostics (Basel)*. [Review / Meta-Analysis]
Bardhan M (2026). [PMID: 32644361](https://pubmed.ncbi.nlm.nih.gov/32644361/). *Unknown Journal*. [Review / Meta-Analysis]
Plancha M Sr (2025). [PMID: 40698227](https://pubmed.ncbi.nlm.nih.gov/40698227/). *Cureus*. [Case Report / Case Series]
Draxler J (2024). [PMID: 38492082](https://pubmed.ncbi.nlm.nih.gov/38492082/). *Arch Gynecol Obstet*. [Epidemiology / Natural History]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 5:33 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Financial & Access Support (External Programs)

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Myasthenia Gravis Medical Assistance

Medical AssistanceCurrently AcceptingOperated by National Organization for Rare Disorders

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Medical References

Questions for Your Care Team

→What are the benefits and potential side effects of PYRIDOSTIGMINE BROMIDE for managing neonatal myasthenia gravis?
→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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neonatal myasthenia gravis

Overview

Treatment

Approved Therapies

Research Landscape

Recent Publications

Patient Support

Financial & Access Support (External Programs)

Are you a patient organization for this condition?

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials