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neoplasm of mature B-cells - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

neoplasm of mature B-cells

MONDO:0004949

Also known as:mature B-cell lymphocytic neoplasmmature B-cell neoplasmmature B-cell neoplasms

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Overview

A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Clinical Trials2 registered · 2 recruiting

Diagnosis

Biomarker and diagnostic research for neoplasm of mature B-cells has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered, 2 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE1. Research is sponsored by a mix of industry and academic institutions.

333 publications have been identified in PubMed for neoplasm of mature B-cells. Research spans Basic Science / Preclinical (35%), Review / Meta-Analysis (22%), and Gene Therapy / Novel Therapeutics (17%).

Research Type	Count	% of Total
Laboratory research	118

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 6:09 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
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neoplasm of mature B-cells

Overview

Diagnosis

Research Landscape

Medical References

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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