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neurohypophyseal diabetes insipidus - Clinical Profile, Genes & Research | Kisho | Kisho

Features include very common findings: Diabetes insipidus and Polydipsia; and common findings: Irritability, Lethargy, Growth delay, and Weight loss and others. 17 total HPO annotations.

Organ System	Phenotype Count	Example Features
Bones and joints	2	Decreased circulating osteocalcin level, Mild bone density loss (osteopenia)
Brain and nerves	2	Scarring in the brain (gliosis), Irritability
Hormones	2	Central diabetes insipidus, Diabetes insipidus
Growth and development	2	Growth delay, Weight loss
Digestive system	2	Vomiting, Diarrhea
Lab test results	1	Decreased circulating osteocalcin level
Metabolism	1	Fever

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

11 clinical trials registered, 8 recruiting. Interventions under study include drug therapy, other interventions, and procedural interventions. Pipeline includes 2 PHASE2, 1 PHASE1, 2 EARLY_PHASE1. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06676774](https://clinicaltrials.gov/study/NCT06676774)	Effect of Intranasal Oxytocin on Emotion Recognition and Acute Psycho-Social Stress-induced Cortisol Increase in Patients With Central Diabetes Insipidus and Healthy Controls	PHASE2	University Hospital, Basel, Switzerland	RECRUITING
[NCT06789705](https://clinicaltrials.gov/study/NCT06789705)	Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy Controls	NA	University Hospital, Basel, Switzerland	RECRUITING
[NCT06742060](https://clinicaltrials.gov/study/NCT06742060)	The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU	—	Children's Hospital of Fudan University	RECRUITING
[NCT04789148](https://clinicaltrials.gov/study/NCT04789148)	Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency	PHASE1	Elizabeth Austen Lawson	RECRUITING
[NCT06808516](https://clinicaltrials.gov/study/NCT06808516)	Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Controls	PHASE2	University Hospital, Basel, Switzerland	RECRUITING

176 publications have been identified in PubMed for neurohypophyseal diabetes insipidus. Research spans Case Report / Case Series (30%), Review / Meta-Analysis (19%), and Clinical Trial Publication (16%).

Research Type	Count	% of Total
Patient case studies	52	30%
Research summaries	34	19%
Clinical study results	29	16%
Disease patterns and progression	21	12%
Testing and diagnosis research	20	11%
Laboratory research	17

Recent Publications

Gippert S (2026). [PMID: 39293420](https://pubmed.ncbi.nlm.nih.gov/39293420/). *Horm Res Paediatr*. [Clinical Trial Publication]
Park SS (2026). [PMID: 41603925](https://pubmed.ncbi.nlm.nih.gov/41603925/). *Osteoporos Int*. [Epidemiology / Natural History]
Tuli G (2026). [PMID: 41984305](https://pubmed.ncbi.nlm.nih.gov/41984305/). *Pituitary*. [Clinical Trial Publication]
Nikaj A (2026). [PMID: 42041101](https://pubmed.ncbi.nlm.nih.gov/42041101/). *Endocr Connect*. [Basic Science / Preclinical]
Napper R (2026). [PMID: 41667271](https://pubmed.ncbi.nlm.nih.gov/41667271/). *Archives of disease in childhood*. [Basic Science / Preclinical]
Caputo C (2026). [PMID: 42051284](https://pubmed.ncbi.nlm.nih.gov/42051284/). *JCEM Case Rep*. [Case Report / Case Series]
Iglesias P (2026). [PMID: 42123046](https://pubmed.ncbi.nlm.nih.gov/42123046/). *J Clin Med*. [Review / Meta-Analysis]
Naito S (2026). [PMID: 42036334](https://pubmed.ncbi.nlm.nih.gov/42036334/). *Endocr J*. [Diagnostic / Biomarker]
Caputo C (2026). [PMID: 41583893](https://pubmed.ncbi.nlm.nih.gov/41583893/). *JCEM Case Rep*. [Case Report / Case Series]
Tomkins M (2026). [PMID: 41203493](https://pubmed.ncbi.nlm.nih.gov/41203493/). *Best practice & research. Clinical endocrinology & metabolism*. [Epidemiology / Natural History]

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neurohypophyseal diabetes insipidus

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

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External Resources

OMIM

Orphanet

GARD

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neurohypophyseal diabetes insipidus

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team