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neuronopathy, distal hereditary motor, type 9 (HMN9) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

neuronopathy, distal hereditary motor, type 9

MONDO:0060585

Also known as:HMN9neuronopathy, distal hereditary motor, type IXneuropathy, distal hereditary motor, type 9

Overview

GeneticsAutosomal dominant · WARS1 (chr 14)

ResearchLimited published research (4 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Distal upper limb muscle weakness, Distal lower limb muscle weakness, Motor axonal neuropathy, and Distal upper limb amyotrophy and others; and common findings: Absent patellar reflexes. 10 total HPO annotations.

Organ System	Phenotype Count	Example Features
Arms and legs	4	Distal upper limb muscle weakness, Distal lower limb muscle weakness, Distal upper limb amyotrophy

Genetic Landscape

WARS1 function has not been fully characterized.

Neuronopathy, distal hereditary motor, type 9 is associated with mutations in the WARS1 gene on chromosome 14.

Diagnosis

Genetic testing for WARS1 is available. Testing is considered confirmatory for diagnosis.

Prognosis

Phenotype severity distribution: 6 always present features, 1 common feature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for neuronopathy, distal hereditary motor, type 9.

4 publications have been identified in PubMed for neuronopathy, distal hereditary motor, type 9. Research spans Review / Meta-Analysis (25%), Case Report / Case Series (25%), and Basic Science / Preclinical (25%).

Recent Publications

Antos A (2026). [PMID: 42122051](https://pubmed.ncbi.nlm.nih.gov/42122051/). *Diagnostics (Basel)*. [Review / Meta-Analysis]
Mercan M (2025). [PMID: 40085521](https://pubmed.ncbi.nlm.nih.gov/40085521/). *Amyotroph Lateral Scler Frontotemporal Degener*. [Case Report / Case Series]
Stanworth M (2024). [PMID: 39480826](https://pubmed.ncbi.nlm.nih.gov/39480826/). *PLoS One*. [Basic Science / Preclinical]
Jiménez-Jiménez J (2024). [PMID: 39051710](https://pubmed.ncbi.nlm.nih.gov/39051710/). *Eur J Neurol*. [Epidemiology / Natural History]

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 4:32 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:617721

Questions for Your Care Team

→Should I pursue genetic testing for WARS1, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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neuronopathy, distal hereditary motor, type 9

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

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Questions for Your Care Team

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