FGFR3
FGFR3 encodes fibroblast growth factor receptor 3 (806 aa). Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Highest expression in Skin Not Sun Exposed Suprapubic (364.5 TPM) and Skin Sun Exposed Lower leg (356.5 TPM).
Nevus, epidermal is associated with mutations in the FGFR3 gene on chromosome 4.
FGFR3 is classified as a druggable target (Cell Surface, Clinically Actionable, Drug Resistance, Druggable Genome, Kinase, and Tyrosine Kinase categories) with score 1.6.
HRAS
HRAS encodes HRas proto-oncogene, GTPase (189 aa). Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
Nevus, epidermal is associated with mutations in the HRAS gene on chromosome 11.
The HRAS protein participates in S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated pathway.
HRAS is classified as a druggable target (Clinically Actionable, Drug Resistance, Druggable Genome, Enzyme, and Tumor Suppressor categories) with score 0.8.
NRAS
NRAS encodes NRAS proto-oncogene, GTPase (189 aa). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity Highest expression in Cells EBV-transformed lymphocytes (77.3 TPM) and Cells Cultured fibroblasts (52.5 TPM).
Nevus, epidermal is associated with mutations in the NRAS gene on chromosome 1.
The NRAS protein participates in S-Farn-Me KRAS4A, HRAS, NRAS and S-Farn-Me PalmS KRAS4A,HRAS, NRAS pathways.
NRAS is classified as a druggable target (Clinically Actionable, Drug Resistance, and Enzyme categories) with score 0.8.
PIK3CA
PIK3CA function has not been fully characterized.
Nevus, epidermal is associated with mutations in the PIK3CA gene on chromosome 3.
