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A immunodeficiency disorder caused by loss of function mutation in NIK (MAP3K14).
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for NIK deficiency.
5 publications have been identified in PubMed for NIK deficiency. Research spans Basic Science / Preclinical (80%) and Case Report / Case Series (20%).
Pan Q (2026). [PMID: 41268333](https://pubmed.ncbi.nlm.nih.gov/41268333/). *Cytotechnology*. [Basic Science / Preclinical]
Zhang W (2026). [PMID: 41391683](https://pubmed.ncbi.nlm.nih.gov/41391683/). *Life Sci*. [Basic Science / Preclinical]
Ozcan A (2026). [PMID: 42175627](https://pubmed.ncbi.nlm.nih.gov/42175627/). *FEBS J*. [Basic Science / Preclinical]
Köstel Bal S (2025). [PMID: 41280889](https://pubmed.ncbi.nlm.nih.gov/41280889/). *Front Immunol*. [Case Report / Case Series]
Baeza C (2024). [PMID: 39519026](https://pubmed.ncbi.nlm.nih.gov/39519026/). *Int J Mol Sci*. [Basic Science / Preclinical]
Data assembled from 3 of 12 sources · Last updated Oct 3, 2026, 6:35 AM UTC
Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about NIK deficiency