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nodular cutaneous amyloidosis (PLCNA) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

nodular cutaneous amyloidosis

MONDO:0015302

Also known as:PLCNAamyloidosis nodular localised cutaneousamyloidosis nodular localized cutaneous

Overview

Primary localized cutaneous nodular amyloidosis (PLCNA) is the most rare form of primary cutaneous amyloidosis, a skin disease characterized by the accumulation of amyloid deposits in the dermis, characterized clinically by yellowish waxy crusted nodules and papules on the face, lower extremities, trunk, scalp, and genitalia and histologically by the localized deposition of immunoglobulin-derived amyloid in the papillary dermis and subcutis. PLCNA can be associated with connective tissue disorders such as SjC6grenBs syndrome and CREST syndrome.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for nodular cutaneous amyloidosis.

14 publications have been identified in PubMed for nodular cutaneous amyloidosis. Research spans Case Report / Case Series (64%), Review / Meta-Analysis (21%), and Other (14%).

Research Type	Count	% of Total
Patient case studies	9	64%

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:54 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:137810

GARD

Genetic and Rare Diseases Info Center

GARD:10562

Questions for Your Care Team

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nodular cutaneous amyloidosis

Overview

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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