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Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for non-syndromic metopic and sagittal craniosynostosis.
9 publications have been identified in PubMed for non-syndromic metopic and sagittal craniosynostosis. Research spans Epidemiology / Natural History (44%), Review / Meta-Analysis (22%), and Basic Science / Preclinical (22%).
Harrison LM (2026). [PMID: 42132426](https://pubmed.ncbi.nlm.nih.gov/42132426/). *Cleft Palate Craniofac J*. [Epidemiology / Natural History]
Liu Z (2025). [PMID: 40353334](https://pubmed.ncbi.nlm.nih.gov/40353334/). *Mol Genet Genomic Med*. [Basic Science / Preclinical]
Weinfeld J (2025). [PMID: 39639505](https://pubmed.ncbi.nlm.nih.gov/39639505/). *Cleft Palate Craniofac J*. [Epidemiology / Natural History]
Alperovich M (2025). [PMID: 40210850](https://pubmed.ncbi.nlm.nih.gov/40210850/). *Nat Rev Dis Primers*. [Review / Meta-Analysis]
Ferriastuti W (2024). [PMID: 39777176](https://pubmed.ncbi.nlm.nih.gov/39777176/). *Surg Neurol Int*. [Epidemiology / Natural History]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:33 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Walton IS (2024). [PMID: 38760592](https://pubmed.ncbi.nlm.nih.gov/38760592/). *J Anat*. [Basic Science / Preclinical]
Al-Murad BM (2024). [PMID: 38910614](https://pubmed.ncbi.nlm.nih.gov/38910614/). *Cureus*. [Review / Meta-Analysis]
Moreno-Villagómez J (2024). [PMID: 36840597](https://pubmed.ncbi.nlm.nih.gov/36840597/). *Appl Neuropsychol Child*. [Clinical Trial Publication]
Ntoula E (2024). [PMID: 38148500](https://pubmed.ncbi.nlm.nih.gov/38148500/). *Acta Ophthalmol*. [Epidemiology / Natural History]