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A small, benign, bone-forming neoplasm that can arise from any bone but more frequently affects the long bones. The central portion of the neoplasm (nidus) contains differentiated osteoblasts which produce osteoid and sometimes bone. The lesion is usually surrounded by hypervascular sclerotic bone and has limited growth potential. Clinical signs and symptoms include pain and localized tenderness, at the site of the lesion. The pain may be intense but in the majority of cases it is completely alleviated by non-steroidal anti-inflammatory drugs. Prognosis is excellent and recurrences are rare.
Biomarker and diagnostic research for osteoid osteoma has been reported in the published literature.
3 clinical trials registered, 1 recruiting. Interventions under study include medical devices. Pipeline includes 1 PHASE3, 1 PHASE2, 1 NA. Research is primarily sponsored by academic and government institutions.
153 publications have been identified in PubMed for osteoid osteoma. Research spans Case Report / Case Series (52%), Review / Meta-Analysis (17%), and Clinical Trial Publication (12%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 67 |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 1:00 AM UTC
Online Mendelian Inheritance in Man
Research summaries | 22 | 17% |
Clinical study results | 15 | 12% |
Testing and diagnosis research | 9 | 7% |
Other research | 8 | 6% |
Disease patterns and progression | 5 | 4% |
Laboratory research | 4 | 3% |
Rarchaert M (2026). [PMID: 41276117](https://pubmed.ncbi.nlm.nih.gov/41276117/). *J ISAKOS*. [Case Report / Case Series]
Steffen DA (2026). [PMID: 41670885](https://pubmed.ncbi.nlm.nih.gov/41670885/). *Radiol Med*. [Diagnostic / Biomarker]
Inarejos Clemente EJ (2026). [PMID: 41396196](https://pubmed.ncbi.nlm.nih.gov/41396196/). *Pediatr Radiol*. [Review / Meta-Analysis]
Davis D (2026). [PMID: 42273455](https://pubmed.ncbi.nlm.nih.gov/42273455/). *J Orthop Case Rep*. [Case Report / Case Series]
Thompson RE (2026). [PMID: 42128340](https://pubmed.ncbi.nlm.nih.gov/42128340/). *J Vasc Interv Radiol*. [Basic Science / Preclinical]
Rampure AH (2026). [PMID: 42131027](https://pubmed.ncbi.nlm.nih.gov/42131027/). *J Orthop Case Rep*. [Case Report / Case Series]
Wintergerst C (2026). [PMID: 41876692](https://pubmed.ncbi.nlm.nih.gov/41876692/). *Cardiovasc Intervent Radiol*. [Epidemiology / Natural History]
Le Corroller T (2026). [PMID: 41545718](https://pubmed.ncbi.nlm.nih.gov/41545718/). *Skeletal Radiol*. [Review / Meta-Analysis]
Vennik AMF (2026). [PMID: 41549645](https://pubmed.ncbi.nlm.nih.gov/41549645/). *Bone Jt Open*. [Epidemiology / Natural History]
Dong H (2026). [PMID: 41325452](https://pubmed.ncbi.nlm.nih.gov/41325452/). *J Bone Joint Surg Am*. [Clinical Trial Publication]