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Necrosis of bone following radiation injury.
Biomarker and diagnostic research for osteoradionecrosis has been reported in the published literature.
9 clinical trials registered, 3 recruiting. Interventions under study include other interventions, procedural interventions, and drug therapy. Pipeline includes 1 PHASE4, 1 PHASE3, 2 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT04265430](https://clinicaltrials.gov/study/NCT04265430) |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:12 PM UTC
Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors |
PHASE4 |
M.D. Anderson Cancer Center |
RECRUITING |
[NCT05412849](https://clinicaltrials.gov/study/NCT05412849) | Radiation Field, Dose and Fractionation Related to Mandibular Complications | — | Lund University Hospital | UNKNOWN |
[NCT06055257](https://clinicaltrials.gov/study/NCT06055257) | Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible | PHASE3 | Sunnybrook Health Sciences Centre | RECRUITING |
[NCT05325970](https://clinicaltrials.gov/study/NCT05325970) | Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients | — | Wake Forest University Health Sciences | UNKNOWN |
[NCT02661139](https://clinicaltrials.gov/study/NCT02661139) | Prospective Registry of Prosthodontic Rehabilitation in Oncology Patients Undergoing Jaw Reconstruction | — | AZ Sint-Jan AV | RECRUITING |
245 publications have been identified in PubMed for osteoradionecrosis. Kisho has analyzed 155 by research type. Research spans Review / Meta-Analysis (46%), Clinical Trial Publication (15%), and Epidemiology / Natural History (14%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 71 | 46% |
Clinical study results | 23 | 15% |
Disease patterns and progression | 21 | 14% |
Patient case studies | 13 | 8% |
Testing and diagnosis research | 10 | 6% |
Laboratory research | 10 | 6% |
Other research | 4 | 3% |
New treatment approaches | 3 | 2% |
Li Y (2026). [PMID: 41715285](https://pubmed.ncbi.nlm.nih.gov/41715285/). *Adv Mater*. [Clinical Trial Publication]
Costantino A (2026). [PMID: 41392779](https://pubmed.ncbi.nlm.nih.gov/41392779/). *Head Neck*. [Diagnostic / Biomarker]
Bencze B (2026). [PMID: 42021276](https://pubmed.ncbi.nlm.nih.gov/42021276/). *BMC Oral Health*. [Review / Meta-Analysis]
Alexandru GC (2026). [PMID: 42075512](https://pubmed.ncbi.nlm.nih.gov/42075512/). *Medicina (Kaunas)*. [Review / Meta-Analysis]
Kovarik PD (2026). [PMID: 41702133](https://pubmed.ncbi.nlm.nih.gov/41702133/). *Clin Oncol (R Coll Radiol)*. [Epidemiology / Natural History]
Vos DJ (2026). [PMID: 41689432](https://pubmed.ncbi.nlm.nih.gov/41689432/). *Laryngoscope*. [Clinical Trial Publication]
Hegab DM (2026). [PMID: 42216008](https://pubmed.ncbi.nlm.nih.gov/42216008/). *BMC Oral Health*. [Basic Science / Preclinical]
Matar DY (2026). [PMID: 41043770](https://pubmed.ncbi.nlm.nih.gov/41043770/). *J Stomatol Oral Maxillofac Surg*. [Basic Science / Preclinical]
Ribeiro MTL (2026). [PMID: 41714790](https://pubmed.ncbi.nlm.nih.gov/41714790/). *Support Care Cancer*. [Review / Meta-Analysis]
Danskin Y (2026). [PMID: 41781752](https://pubmed.ncbi.nlm.nih.gov/41781752/). *Support Care Cancer*. [Diagnostic / Biomarker]