Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

parenteral nutrition-associated cholestasis (PNAC) - Clinical Profile, Treatments & Trials | Kisho | Kisho

Rare Disease

parenteral nutrition-associated cholestasis

MONDO:0035777

Also known as:PNAC

Overview

A rare hepatic disease characterized by intrahepatic cholestasis and deterioration of liver function in patients receiving parenteral nutrition for extended periods of time (signs may appear as early as within the first two weeks of initiation of parenteral nutrition). The condition commonly occurs in neonates and usually resolves with transition to enteral feeding, although severe cases may progress to liver fibrosis, cirrhosis, and portal hypertension.

Treatments3 FDA approved

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

3 FDA-approved treatments are available for parenteral nutrition-associated cholestasis, including DEXTROSE (DEXTROSE, approved 1985), SMOFLIPID (SMOFLIPID, approved 2016), and FISH OIL (OMEGAVEN, approved 2018).

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for parenteral nutrition-associated cholestasis.

19 publications have been identified in PubMed for parenteral nutrition-associated cholestasis. Research spans Clinical Trial Publication (32%), Basic Science / Preclinical (32%), and Epidemiology / Natural History (32%).

Research Type	Count	% of Total
Clinical study results	6	32%

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 3:56 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:567983

GARD

Genetic and Rare Diseases Info Center

GARD:22295

Questions for Your Care Team

→What are the benefits and potential side effects of DEXTROSE for managing parenteral nutrition-associated cholestasis?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Kisho

parenteral nutrition-associated cholestasis

Overview

Treatment

Approved Therapies

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

parenteral nutrition-associated cholestasis

Overview

Treatment

Approved Therapies

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications