Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

patent foramen ovale - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

patent foramen ovale

MONDO:0020439

Also known as:atrial septal defect within oval fossadefect, patent or persistent, ostium secundumforamen ovale patent

Find Clinical TrialsTrials

Overview

A persistent opening in the atrial septum after birth. While a normal part of fetal circulation, the foramen ovale should close once the newborn begins breathing and the pressure in the left atrium exceeds that of the right atrium. While a PFO is generally asymptomatic, it can lead to the passage of clots from the venous circulation into the artierial circulation, resulting in paradoxical emboli, and possible strokes.

Clinical Trials40 registered · 14 recruiting

Diagnosis

Biomarker and diagnostic research for patent foramen ovale has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

40 clinical trials registered, 14 recruiting. Interventions under study include medical devices, other interventions, drug therapy, and procedural interventions. Pipeline includes 4 PHASE3, 18 NA. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07172464](https://clinicaltrials.gov/study/NCT07172464)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 2:53 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:99108

Questions for Your Care Team

→Are any of the 40 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Research summaries	47	43%
Clinical study results	15	14%
Disease patterns and progression	15	14%
Other research	9	8%
Patient case studies	9	8%
Testing and diagnosis research	7	6%
Laboratory research	6	6%
New treatment approaches	1	1%

Kisho

patent foramen ovale

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Thrombus in Transit Through a Patent Foramen Ovale: A Clinical Conundrum.

Platypnea-Orthodeoxia Syndrome Caused by a Patent Foramen Ovale and Interatrial Septal Aneurysm: A Case Report.

Thrombus-In-Transit Across Patent Foramen Ovale Causing Dynamic Embolism to the Left Main Coronary and Pulmonary Arteries.

patent foramen ovale

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Thrombus in Transit Through a Patent Foramen Ovale: A Clinical Conundrum.

Platypnea-Orthodeoxia Syndrome Caused by a Patent Foramen Ovale and Interatrial Septal Aneurysm: A Case Report.

Thrombus-In-Transit Across Patent Foramen Ovale Causing Dynamic Embolism to the Left Main Coronary and Pulmonary Arteries.