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Pediatric hepatocellular carcinoma (pediatric HCC) is a rare, aggressive, malignant hepatic tumor that develops mainly in children over 10 years of age.
Features include very common findings: Liver scarring (fibrosis) (hepatic fibrosis), Abdominal pain, Enlarged liver (hepatomegaly), and Elevated circulating alpha-fetoprotein concentration; and common findings: Vomiting, Hepatic necrosis, Fatigue, and Portal vein thrombosis and others.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Digestive system | 5 | Liver scarring (fibrosis) (hepatic fibrosis), Abdominal pain, Enlarged liver (hepatomegaly) |
Lab test results | 1 | Elevated circulating alpha-fetoprotein concentration |
Brain and nerves | 1 | Fatigue |
Biomarker and diagnostic research for pediatric hepatocellular carcinoma has been reported in the published literature.
Phenotype severity distribution: 4 very common features, 5 common features.
Estimated prevalence: Unknown (Unknown prevalence).
1 clinical trial registered. Interventions under study include drug therapy, other interventions, and procedural interventions. Pipeline includes 1 PHASE3. Research is primarily sponsored by academic and government institutions.
215 publications have been identified in PubMed for pediatric hepatocellular carcinoma. Research spans Basic Science / Preclinical (38%), Review / Meta-Analysis (22%), and Epidemiology / Natural History (12%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 82 | 38% |
Research summaries | 47 | 22% |
Disease patterns and progression | 26 | 12% |
New treatment approaches | 19 | 9% |
Testing and diagnosis research | 13 | 6% |
Clinical study results | 12 | 6% |
Patient case studies | 9 | 4% |
Other research | 5 | 2% |
Zhang J (2026). [PMID: 41536919](https://pubmed.ncbi.nlm.nih.gov/41536919/). *Bioactive materials*. [Gene Therapy / Novel Therapeutics]
Yu J (2026). [PMID: 42082186](https://pubmed.ncbi.nlm.nih.gov/42082186/). *Pediatrics*. [Case Report / Case Series]
Ying S (2026). [PMID: 41883040](https://pubmed.ncbi.nlm.nih.gov/41883040/). *Aliment Pharmacol Ther*. [Other]
Xing J (2026). [PMID: 41850287](https://pubmed.ncbi.nlm.nih.gov/41850287/). *Cell*. [Gene Therapy / Novel Therapeutics]
R T (2026). [PMID: 41834287](https://pubmed.ncbi.nlm.nih.gov/41834287/). *Pediatric blood & cancer*. [Case Report / Case Series]
Huang J (2026). [PMID: 40617410](https://pubmed.ncbi.nlm.nih.gov/40617410/). *J Adv Res*. [Basic Science / Preclinical]
Massoudi D (2026). [PMID: 41678777](https://pubmed.ncbi.nlm.nih.gov/41678777/). *Hepatology*. [Review / Meta-Analysis]
Valenzuela-Pérez L (2026). [PMID: 42141897](https://pubmed.ncbi.nlm.nih.gov/42141897/). *Hepatology*. [Basic Science / Preclinical]
Song IH (2026). [PMID: 40369749](https://pubmed.ncbi.nlm.nih.gov/40369749/). *Cancer Res Treat*. [Epidemiology / Natural History]
El-Kholy O (2026). [PMID: 41759482](https://pubmed.ncbi.nlm.nih.gov/41759482/). *Curr Res Transl Med*. [Review / Meta-Analysis]
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 6:55 PM UTC
Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.
European rare disease database
Genetic and Rare Diseases Info Center
AI-curated news mentioning pediatric hepatocellular carcinoma
Updated Sep 17, 2026
A new study presents a noninvasive model for predicting clinically significant portal hypertension in patients with hepatocellular carcinoma. This tumor-adjusted approach could enhance patient management and treatment strategies.
Research reveals that Mint3 modulates the AHR signaling pathway to suppress cuproptosis, thereby facilitating the progression of hepatocellular carcinoma. This discovery could inform future therapeutic strategies targeting this cancer.
A recent pathological study highlights the distinct growth patterns between hepatic alveolar echinococcosis and hepatocellular carcinoma. This research could inform future diagnostic and treatment strategies for these conditions.
BeOne Medicines has received a UK innovation passport for its investigational antibody therapy targeting hepatocellular carcinoma (HCC), facilitating accelerated access to the treatment. This designation underscores the potential of the therapy in addressing a critical need in cancer care.