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Pediatric hepatocellular carcinoma (pediatric HCC) is a rare, aggressive, malignant hepatic tumor that develops mainly in children over 10 years of age.
Features include very common findings: Liver scarring (fibrosis) (hepatic fibrosis), Abdominal pain, Enlarged liver (hepatomegaly), and Elevated circulating alpha-fetoprotein concentration; and common findings: Vomiting, Hepatic necrosis, Fatigue, and Portal vein thrombosis and others.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Digestive system | 5 | Liver scarring (fibrosis) (hepatic fibrosis), Abdominal pain, Enlarged liver (hepatomegaly) |
Lab test results | 1 | Elevated circulating alpha-fetoprotein concentration |
Brain and nerves | 1 | Fatigue |
Biomarker and diagnostic research for pediatric hepatocellular carcinoma has been reported in the published literature.
Phenotype severity distribution: 4 very common features, 5 common features.
Estimated prevalence: Unknown (Unknown prevalence).
1 clinical trial registered. Interventions under study include drug therapy, other interventions, and procedural interventions. Pipeline includes 1 PHASE3. Research is primarily sponsored by academic and government institutions.
215 publications have been identified in PubMed for pediatric hepatocellular carcinoma. Research spans Basic Science / Preclinical (38%), Review / Meta-Analysis (22%), and Epidemiology / Natural History (12%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 82 | 38% |
Research summaries | 47 | 22% |
Disease patterns and progression | 26 | 12% |
New treatment approaches | 19 | 9% |
Testing and diagnosis research | 13 | 6% |
Clinical study results | 12 | 6% |
Patient case studies | 9 | 4% |
Other research | 5 | 2% |
Zhang J (2026). [PMID: 41536919](https://pubmed.ncbi.nlm.nih.gov/41536919/). *Bioactive materials*. [Gene Therapy / Novel Therapeutics]
Yu J (2026). [PMID: 42082186](https://pubmed.ncbi.nlm.nih.gov/42082186/). *Pediatrics*. [Case Report / Case Series]
Ying S (2026). [PMID: 41883040](https://pubmed.ncbi.nlm.nih.gov/41883040/). *Aliment Pharmacol Ther*. [Other]
Xing J (2026). [PMID: 41850287](https://pubmed.ncbi.nlm.nih.gov/41850287/). *Cell*. [Gene Therapy / Novel Therapeutics]
R T (2026). [PMID: 41834287](https://pubmed.ncbi.nlm.nih.gov/41834287/). *Pediatric blood & cancer*. [Case Report / Case Series]
Huang J (2026). [PMID: 40617410](https://pubmed.ncbi.nlm.nih.gov/40617410/). *J Adv Res*. [Basic Science / Preclinical]
Massoudi D (2026). [PMID: 41678777](https://pubmed.ncbi.nlm.nih.gov/41678777/). *Hepatology*. [Review / Meta-Analysis]
Valenzuela-Pérez L (2026). [PMID: 42141897](https://pubmed.ncbi.nlm.nih.gov/42141897/). *Hepatology*. [Basic Science / Preclinical]
Song IH (2026). [PMID: 40369749](https://pubmed.ncbi.nlm.nih.gov/40369749/). *Cancer Res Treat*. [Epidemiology / Natural History]
El-Kholy O (2026). [PMID: 41759482](https://pubmed.ncbi.nlm.nih.gov/41759482/). *Curr Res Transl Med*. [Review / Meta-Analysis]
Data assembled from 5 of 12 sources · Last updated Nov 3, 2026, 7:32 PM UTC
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European rare disease database
Genetic and Rare Diseases Info Center
AI-curated news mentioning pediatric hepatocellular carcinoma
Updated Oct 5, 2026
A recent study compares stereotactic ablative body radiotherapy (SABR) and microwave ablation for treating early-stage hepatocellular carcinoma. The findings contribute to understanding treatment efficacy in this patient population.
A case report details left medial liver lobe torsion linked to hepatocellular carcinoma in a Pembroke Welsh Corgi. This study contributes to the understanding of liver conditions in veterinary medicine.
A case report highlights the use of DEB-TACE in combination with immunotherapy and targeted therapy for treating advanced hepatocellular carcinoma with scapular metastasis. This approach may provide insights into novel treatment strategies for this challenging cancer.
BeOne Medicines has received a UK innovation passport for its investigational antibody therapy targeting hepatocellular carcinoma (HCC), facilitating accelerated access to the treatment. This designation underscores the potential of the therapy in addressing a critical need in cancer care.