Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy
A rare, genetic form of hypophosphatasia (HPP) characterized by markedly impaired bone mineralization in utero due to reduced activity of serum alkaline phosphatase (ALP) and causing stillbirth or respiratory failure within days of birth.
Estimated prevalence: Unknown (Unknown prevalence).
1 clinical trial registered, 1 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.
2 publications have been identified in PubMed for perinatal lethal hypophosphatasia. Research spans Basic Science / Preclinical (50%) and Epidemiology / Natural History (50%).
Carrillo MA (2026). [PMID: 41814653](https://pubmed.ncbi.nlm.nih.gov/41814653/). *Mol Ther*. [Basic Science / Preclinical]
Rojas Martínez JA (2024). [PMID: 39506814](https://pubmed.ncbi.nlm.nih.gov/39506814/). *Orphanet J Rare Dis*. [Epidemiology / Natural History]
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 2:55 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center