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perinatal necrotizing enterocolitis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

perinatal necrotizing enterocolitis

MONDO:0004639

Also known as:enterocolitis necrotizingnecrotizing enterocolitisnecrotizing enterocolitis in fetus or newborn

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Overview

A fulminating disease of neonates in which there is extensive mucosal ulceration, pseudomembrane formation, submucosal hemorrhage, and necrosis usually of the right colon, cecum, terminal ileum, and appendix, possibly due to perinatal intestinal ischemia and bacterial invasion. Progression can lead to necrosis, perforation and/or scarring of the intestinal tract.

Clinical Trials46 registered · 13 recruiting

Diagnosis

Biomarker and diagnostic research for perinatal necrotizing enterocolitis has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

46 clinical trials registered, 13 recruiting. Interventions under study include other interventions, biologic therapy, drug therapy, and gene therapy. Pipeline includes 2 PHASE4, 2 PHASE3, 2 PHASE2. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06315738](https://clinicaltrials.gov/study/NCT06315738)

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 4:55 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→Are any of the 46 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	21	38%
Disease patterns and progression	16	29%
Clinical study results	9	16%
Laboratory research	8	14%
Testing and diagnosis research	1	2%
Patient case studies	1	2%

Kisho

perinatal necrotizing enterocolitis

Overview

Diagnosis

Research Landscape

Medical References

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

[Berberine attenuates necrotizing enterocolitis-associated brain injury via the TLR4/MyD88/NF-κB/NLRP3 pathway].

[Effect of intraoperative hypothermia on short-term prognosis in neonatal necrotizing enterocolitis].

Necrotizing enterocolitis is exacerbated through SUCNR1/HIF-1α/BNIP3 axis-mediated succinate-induced intestinal epithelial cell apoptosis.

perinatal necrotizing enterocolitis

Overview

Diagnosis

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

[Berberine attenuates necrotizing enterocolitis-associated brain injury via the TLR4/MyD88/NF-κB/NLRP3 pathway].

[Effect of intraoperative hypothermia on short-term prognosis in neonatal necrotizing enterocolitis].

Necrotizing enterocolitis is exacerbated through SUCNR1/HIF-1α/BNIP3 axis-mediated succinate-induced intestinal epithelial cell apoptosis.