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pernicious anemia - Clinical Profile, Treatments & Trials | Kisho | Kisho

Rare Disease

pernicious anemia

MONDO:0008228

Also known as:Addison anaemiaAddison anemiaAddison's anaemia

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Overview

Megaloblastic anemia caused by vitamin B-12 deficiency due to impaired absorption. The impaired absorption of vitamin B-12 is secondary to atrophic gastritis and loss of gastric parietal cells.

GeneticsAutosomal dominant

Treatments1 FDA approved

Clinical Trials1 registered

Clinical Presentation

Features include: Malabsorption of Vitamin B12 and Megaloblastic anemia.

Organ System	Phenotype Count	Example Features
Digestive system	1	Malabsorption of Vitamin B12
Blood and immune system	1	Megaloblastic anemia

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Diagnosis

Biomarker and diagnostic research for pernicious anemia has been reported in the published literature.

Treatment

1 FDA-approved treatment is available for pernicious anemia, including CYANOCOBALAMIN (NASCOBAL, approved 2005).

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status
NASCOBAL	CYANOCOBALAMIN	—	2005	Available

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.

151 publications have been identified in PubMed for pernicious anemia. Kisho has analyzed 76 by research type. Research spans Case Report / Case Series (43%), Review / Meta-Analysis (28%), and Epidemiology / Natural History (21%).

Research Type	Count	% of Total
Patient case studies	33

Data assembled from 7 of 12 sources · Last updated Sep 20, 2026, 6:27 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:170900

Orphanet

European rare disease database

Orphanet:120

GARD

Genetic and Rare Diseases Info Center

GARD:12671

Questions for Your Care Team

→What are the benefits and potential side effects of NASCOBAL for managing pernicious anemia?
→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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pernicious anemia

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Treatment

Approved Therapies

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

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